Figure 4. Effect of Dapagliflozin on Hemoglobin A1c and Estimated Glomerular Filtration Rate Among Patients With Heart Failure With and Without Diabetes.
Means and 95% CIs were derived from a mixed-effect model adjusted for baseline values, visit, randomized treatment, and interaction of treatment and visit with a random intercept and slope per patient. Least square mean changes along with 95% CIs are shown. The interaction between diabetes status at baseline and the effect of dapagliflozin, compared with placebo, on each variable of interest over the duration of the trial was tested.