Table 2.

Genetic correlations between sleep phenotypes and PTSD, females only

				Genetic correlation with PTSD
Source†	Phenotype	N	SNP- heritability	r g (SE)	p value
PTSD [17]
PGC, Freeze 1.5	PTSD, binary	15 656 (6128 Ca; 9528 Co)	0.21 (0.05)	—	—
PGC, Freeze 2‡	PTSD, binary	86 600 (12 973 Ca; 73 627 Co)	0.10 (0.02)	—	—
Sleep phenotypes
Lane et al. [19]	Insomnia symptoms,§ binary	30 445 (NR Ca; NR Co)	0.14 (0.02)¶	0.26 (0.10)	0.007*
Hammerschlag et al. [27]	Insomnia symptoms,# binary	59 367 (19 521 Ca; 39 846 Co)	0.08 (0.01)	0.44 (0.12)	0.0002*
Lane et al. [19]	Excessive daytime sleepiness, continuous	59 576	0.06 (0.01)	−0.14 (0.10)e	0.148
Lane et al. [19]	Sleep duration, continuous	59 365	0.08 (0.01)	0.07 (0.11)e	0.498

Ca, cases; Co, controls; NR, not reported; PGC, Psychiatric Genomics Consortium; PTSD, posttraumatic stress disorder; SNP, single nucleotide polymorphism.

^†All sources analyzed data from the UK Biobank. The description “UK Biobank GWAS” refers to a series of analyses conducted on UK Biobank data (2017 release), which can be accessed at: http://www.nealelab.is/blog/2017/7/19/rapid-gwas-of-thousands-of-phenotypes-for-337000-samples-in-the-uk-biobank/ (last accessed May 30, 2019)

^‡This is the PTSD phenotype used for genetic correlations presented in this manuscript; both PTSD heritabilities were scaled to a population prevalence of 30%.

^§Insomnia cases were defined as individuals endorsing “Often” on the sleeplessness item, while controls included individuals endorsing “Never/Rarely.” Individuals endorsing “Sometimes” were designated as missing and not used in analysis.

^#Insomnia cases were defined as individuals endorsing “Often” on the sleeplessness item, while controls were those endorsing “Never/Rarely” and “Sometimes.”

^¶This heritability estimate was not published; instead it was estimated from downloaded summary statistic data using LDSC. Otherwise, the estimate was taken from the original source publication.

*p < 0.05.