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Different drugs have been used to treat HAT depending on the trypanosome subspecies causing the disease, and whether progression is at stage 1 or 2. For the past decade nifurtimox and eflornithine combination therapy has been the treatment of choice for stage 2 T. b. gambiense disease, and pentamidine for stage 1. For rhodesiense HAT, stage 2 is treated with melarsoprol and stage 1 with suramin.
