Table 1.
The survival rates of recombinant five-antigen S. aureus vaccine (rFSAV) and control groups through six repetitions in a S. aureus sepsis model.
| Groups | Survival Rate (10 days) | |||||||
|---|---|---|---|---|---|---|---|---|
| V1 | V2 | V3 | V4 | V5 | V6 | Mean | ||
| Control | His buffer | 0 | 10% | 10% | 20% | 10% | 30% | 16% |
| AlPO4 | 30% | 25% | 20% | 30% | 20% | 30% | 25% | |
| Monovalent | mHIN2 | 10% | 30% | 40% | 30% | 25% | 30% | 27% |
| mSEB | 30% | 11% | 30% | 30% | 30% | 38% | 24% | |
| SpA5 | 70% | 20% | 30% | 35% | 40% | 35% | 40% | |
| MntC | 56% | 0% | 30% | 30% | 35% | 27% | 29% | |
| Bivalent | mHIN2 + mSEB | 45% | 38% | 30% | 60% | 80% | 90% | 60% |
| mHIN2 + SpA5 | 58% | 40% | 50% | 60% | 80% | 80% | 62% | |
| mHIN2 + MntC | 60% | 50% | 25% | 80% | 90% | 100% | 69% | |
| mSEB + SpA5 | 76% | 90% | 60% | 80% | 100% | 60% | 78% | |
| mSEB + MntC | 65% | 70% | 70% | 78% | 60% | 89% | 73% | |
| SpA5 + MntC | 73% | 70% | 80% | 80% | 80% | 90% | 80% | |
| Trivalent | mHIN2 + mSEB + SpA5 | 76% | 100% | 78% | 67% | 67% | 80% | 78% |
| mHIN2 + mSEB + MntC | 71% | 60% | 50% | 80% | 60% | 100% | 70% | |
| mHIN2 + SpA5 + MntC | 70% | 80% | 89% | 67% | 70% | 60% | 73% | |
| mSEB + SpA5 + MntC | 80% | 70% | 90% | 80% | 89% | 90% | 84% | |
| rFSAV | mHIN2 + mSEB + SpA5 + MntC | 90% | 80% | 90% | 85% | 85% | 90% | 87% |
| V710 [24] | IsdB | 70% | 55% | 50% | - | - | - | 58% |