Figure 1.

HA consensus (>50%) sequences of wild-type and escape viruses. Viruses are labeled as in Table 1. NGS sequence data for each escape virus was translated and aligned with the sequence from the input virus. The wild-type virus sequence is underlined an in bold font. Numbering is based on the Yamagata lineage B/Phuket/3073/2013 (PK/WT) sequence. Amino acid sequences common to the PK/WT sequence that differ from the B/Colorado/06/2017 (CO/WT) sequence are highlighted in blue, those common to CO/WT are highlighted in green; mutations resulting in an amino acid not present at levels greater than 50% in the wild-type viruses are shown in pink; and deletions gained through virus passage are highlighted in black. Amino acids associated with known antigenic regions are indicated by yellow bars.