FIG 5.

Visualizing VSV-ANDV escape mutations on a computational model of ANDV Gc. Models of ANDV Gc pre- and postfusion were created using HTNV Gc as the template (prefusion, PDB 5LJY; postfusion, PDB 5LK3). (A) Structural fit of the ANDV prefusion Gc model with 5LJY. (B to D) visualization of escape mutations on the prefusion ANDV Gc model. (E) Structural fit of the ANDV postfusion Gc model (monomer) with 5LK3. (F) Visualization of escape mutations on the postfusion Gc model as a monomer. (G to I) Visualization of escape mutations on the postfusion Gc model as a trimer. Colors shown below panel D are representative for all structures included here. (J) Schematic of ANDV GnGc with escape variants. RMSD, root mean square deviation.