TABLE 1.

MAb characteristics (neutralization, affinity, effector functions, and epitopes)

MAb	Mouse isotype	ELISA (AUC)			Neutralization (IC50)		Effector (ADCC [AUC])	Escape mutation(s) (VSV-ANDV)
		ANDV rGn	VSV-ANDV	VSV-WT	VSV-ANDV	Auth. ANDV
KL-AN-1F12	IgG2a	0.036	2.171	0.080	0.477	0.673	92.68	A871Q
KL-AN-3F6	IgG2b	5.457	4.078	0.095	2.049	1.085	144.90	D121V
KL-AN-4B6	IgG2a	0.013	0.054	0.096	∞	NDa	4.66
KL-AN-4E1	IgG2a	4.129	3.051	0.101	1.013	0.843	65.18	N108K
KL-AN-4G11	IgG2b	5.480	3.420	0.049	1.190	1.433	92.54	K124N
KL-AN-5B3	IgG2a	0.022	0.052	0.030	397.200	ND	2.52
KL-AN-5E8	IgG2b	5.597	2.958	0.028	0.353	1.107	95.72	D121G
KL-AN-5F1	IgG2b	0.022	0.039	0.029	∞	ND	4.12
KL-AN-5F7	IgG2a	0.024	0.084	0.023	92.780	ND	3.72
KL-AN-6B2	IgG2b	0.057	2.283	0.055	∞	ND	3.61
KL-HAP-1D4	IgG2a	0.015	0.049	0.080	1,035	ND	8.30
KL-HAP-1D8	IgG2a	0.015	0.059	0.080	∞	ND	11.65
KL-HAP-2D11	IgG1	0.019	2.132	0.040	2.782	1.325	8.46	S831Y
KL-HAP-2F7	IgG1	0.022	2.296	0.044	3.768	2.303	6.91	P830S
KL-HAP-4E5	IgG2a	0.018	2.297	0.085	0.543	3.507	24.07	N939H
KL-HAP-4H6	IgG2a	1.237	2.575	0.030	8.484	0.251	13.69	K225R
KL-HAP-5G4	IgG2a	0.026	2.294	0.020	2.420	5.355	63.84	S883R; N939D; C1129F
KL-HAP-5H9	IgG2a	0.034	2.154	0.066	2.073	4.692	98.65	N939D; C1129F
KL-HAP-6B12	IgG2a	0.054	1.713	0.248	3.001	20.970	54.30	S883I; N939D
Positive control	IgG2a	3.079	6.782	7.262	ND	ND	66.45
Negative control	IgG2a	0.027	0.056	0.031	∞	0.000

^aND, not determined.