TABLE 2.
Inoculation schedule and inoculum type for 28 animalsa
| Animal ID | Inoculum |
Stock type | Dose |
Route | ||
|---|---|---|---|---|---|---|
| SHIV strain | Position 375 variant(s) | ng of p27 used for each variant |
Total ng of p27 used for each animal |
|||
| RM196 | SHIV 191859 | S and M | 293T | 250 | 1,000 | i.r. |
| SHIV 191859 gp41 | S and M | |||||
| RM194 | SHIV 191859 | S and M | 293T | 250 | 2,000 | i.r. |
| SHIV 191859 gp41 | S and M | |||||
| RM131 | SHIV 191859 | S, M, H, Y, F, and W | 293T | 166 | 1,000 | i.v. |
| RM138 | SHIV 191859 | S, M, H, Y, F, and W | 293T | 166 | 1,000 | i.v. |
| RM6434 | SHIV BG505 332N | S, M, H, Y, F, and W | 293T | 50 | 300 | i.v. |
| RM6442 | SHIV BG505 332N | S, M, H, Y, F, and W | 293T | 50 | 300 | i.v. |
| RM6446 | SHIV BG505 332T | S, M, H, Y, F, and W | 293T | 50 | 300 | i.v. |
| RM6454 | SHIV BG505 332N | S, M, H, Y, F, and W | 293T | 50 | 600 | i.v. |
| SHIV BG505 332T | S, M, H, Y, F, and W | |||||
| RM43335 | SHIV BG505 332N | S, M, H, Y, F, and W | 293T | 50 | 600 | i.v. |
| SHIV BG505 332T | S, M, H, Y, F, and W | |||||
| RM6718 | SHIV BG505 332N | Y | RhCD4+ T cells | 8 | 8 | i.r. |
| RM6719 | SHIV BG505 332N | Y | RhCD4+ T cells | 8 | 8 | i.r. |
| RMT283 | SHIV BG505 332N | Y | RhCD4+ T cells | 1.5 | 1.5 | i.r. |
| RM6715 | SHIV BG505 332N | Y | RhCD4+ T cells | 8 | 8 | i.r. |
| RM6706 | SHIV BG505 332N | Y | RhCD4+ T cells | 1.5 | 1.5 | i.r. |
| RM6708 | SHIV BG505 332N | Y | RhCD4+ T cells | 1.5 | 1.5 | i.r. |
| RM6717 | SHIV BG505 332N | Y | RhCD4+ T cells | 8 | 8 | i.r. |
| RM08N021 | SHIV BG505 332N | Y | RhCD4+ T cells | 1 | 1 | i.r. |
| RM10N011 | SHIV BG505 332N | Y | RhCD4+ T cells | 1 | 1 | i.r. |
| RM6072 | SHIV CH505 | S, M, H, Y, F, and W | 293T | 500 | 3,000 | i.v. |
| RM5694 | SHIV CH505 | H in 3 different backbones | 293T | 5 | 15 | i.v. |
| RMT775 | SHIV CH505 | H in 3 different backbones | 293T | 5 | 15 | i.v. |
| RMT943 | SHIV CH848 1017 | H | 293T | 50 | 100 | i.v. |
| SHIV CH848 1017DT | H | |||||
| RMT944 | SHIV CH848 1017 | H | 293T | 50 | 100 | i.v. |
| SHIV CH848 1017DT | H | |||||
| RMT945 | SHIV CH848 1017 | H | 293T | 50 | 100 | i.v. |
| SHIV CH848 1017DT | H | |||||
| RMT682 | SHIV 1086 | S, M, H, Y, F, and W | 293T | 50 | 300 | i.v. |
| RMT929 | SHIV 1086 | W | 293T | 50 | 50 | i.v. |
| RMT930 | SHIV 1086 | W | 293T | 50 | 50 | i.v. |
| RM41216 | SHIV 40100 | S, M, H, Y, F, and W | 293T | 50 | 300 | i.v. |
The inocula for RM5694 and RMT775 were identical in env gp160 sequence. i.r., intrarectal; i.v., intravenous.