TABLE 1.
Allelic variation during persistent meningococcal carriage
| Clonal complex | Volunteer no. (mo of carriage)a | Isolates (genomes)b | No. of genes |
Mutability/mo of carriage (×10−4) | No. of genes |
||
|---|---|---|---|---|---|---|---|
| Totalc | Variabled | With 1 difference (indel) | With >1 difference | ||||
| cc174 | V51 (6) | N51.1 (28248), N424.1 (28274) | 1,854 | 3 | 2.7 | 3 (0) | 0 |
| V43 (2) | N241.1 (28247), N349.1 (28273) | 1,845 | 1 | 2.7 | 1 (1) | 0 | |
| V52 (3) | N52.1 (28249), N342.1 (28275) | 1,856 | 0 | 0 | 0 | 0 | |
| V58 (6) | N58.1 (28251), N429.1 (28277) | 1,846 | 0 | 0 | 0 | 0 | |
| V59 (6) | N59.1 (28252), N438.1 (28278) | 1,855 | 4 | 3.6 | 4 (0) | 0 | |
| V88 (6) | N88.1 (28253), N449.1 (28279) | 1,860 | 5 | 4.5 | 5 (2) | 0 | |
| V138 (3) | N138.1 (28254), N331.1 (28280) | 1,865 | 4 | 7.1 | 4 (0) | 0 | |
| V54 (3) | N54.1 (28250), N343.1 (28276) | 1,840 | 24 | 43.4 | 24 (2) | 0 | |
| cc167 | V64 (3) | N64.1 (28255), N348.1 (28281) | 1,852 | 2 | 3.6 | 2 (1) | 0 |
| V117 (6) | N117.1 (28256), N417.1 (28282) | 1,850 | 4 | 3.6 | 4 (1) | 0 | |
| V124 (3) | N124.1 (28257), N336.1 (28283) | 1,863 | 4 | 7.2 | 4 (1) | 0 | |
| V128 (6) | N128.1 (28258), N420.1 (28284) | 1,846 | 34 | 30.7 | 9 (2) | 25 | |
| cc23 | V69 (5) | N258.1 (28259), N431.1 (28285) | 1,820 | 0 | 0 | 0 | 0 |
| V93 (2) | N264.1 (28260), N359.1 (28286) | 1,816 | 6 | 16.5 | 6 (1) | 0 | |
| V96 (5) | N259.1 (28261), N445.1 (28287) | 1,833 | 7 | 7.6 | 7 (3) | 0 | |
| V222 (6) | N222.1 (28262), N459.1 (28288) | 1,732 | 8 | 7.7 | 1 | 7 | |
| V188 (6) | N188.1 (28269), N462.1 (28295) | 1,863 | 0 | 0 | 0 | 0 | |
| cc60 | V114 (3) | N114.1 (28263), N330.1 (28289) | 1,797 | 8 | 14.8 | 7 (1) | 1 |
| V134 (3) | N134.1 (28264), N333.1 (28290) | 1,791 | 2 | 3.8 | 1 (0) | 1 | |
| V185 (6) | N185.1 (28265), N185.2 (28266), N456.1 (28291), N456.2 (28292) | 1,823 | 5 | 4.6 | 4 (1) | 1 | |
| cc1157 | V73 (6) | N73.1 (28268), N450.1 (28294) | 1,838 | 3 | 2.7 | 3 (0) | 0 |
| V82 (5) | N262.1 (28267), N446.1 (28293) | 1,843 | 10 | 9.0 | 2 (0) | 8 | |
| cc269 | V199 (3) | N199.1 (28270), N378.1 (28296) | 1,947 | 1 | 1.7 | 1 (1) | 0 |
| cc32 | V176 (6) | N176.1 (28271), N408.1 (28297) | 1,974 | 1 | 0.8 | 1 (1) | 0 |
| V86 (6) | N86.1 (28272), N447.1 (28298) | 1,794 | 2 | 1.9 | 2 (0) | 0 | |
a
Note that each pair of isolates is of the same sequence type and that carriage spanned between 2 and 6 months.
b
Isolate number (number allocated to the genome sequence of that isolate in the PubMLST/neisseria database).
c
Total number of analyzed genes excluding truncated genes (average of 41/genome) and duplicated or multicopy genes (e.g., insertion elements [IS], pilE/pilS, and multigene families).
d
Gene sequences having one or more nucleotide differences between the two paired isolates.