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. 2020 Feb 25;9(3):154. doi: 10.3390/pathogens9030154

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Maximum-likelihood phylogeny of Orthohepevirus C variants within the genus Orthohepevirus. Representatives of Orthohepevirus A, B, and D variants are reference strains according to the International Committee on Taxonomy of Viruses (ICTV) consensus proposals [11]. Virus designations include GenBank accession numbers and host information. Species and genotypes are indicated on the right. Viral strains from rodent families Muridae and Cricetidae and carnivore family Mustelidae are highlighted with grey, blue, and green background, respectively. Complete genome sequences were aligned using the MAFFT algorithm. Phylogenetic reconstructions were performed using MEGA version 7 with 1000 bootstrap replicates. General Time Reversible (GTR) + Gamma Distributed (G) + Invariable Sites (I) nucleotide substitution model was selected based on Find Best-Fit Substitution Model (ML) in MEGA version 7. Bootstrap values (>75%) are indicated at specific nodes. Scale bars indicate the number of nucleotide substitutions per site.