Table 2.
Minimal inhibitory concentration (MIC, mg/mL) and minimal bactericidal concentration (MBC, mg/mL) of selected TCMP extracts against multidrug-resistant S. aureus.
| No. | Scientific Name | S. aureus | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ATCC 25923 | SJTUF 20745 | SJTUF 20746 | SJTUF 20758 | SJTUF 20827 | SJTUF 20978 | SJTUF 20991 | |||||||||
| MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | ||
| (mg/mL) | (mg/mL) | (mg/mL) | (mg/mL) | (mg/mL) | (mg/mL) | (mg/mL) | |||||||||
| 3 | Rhus chinensis Mill. | 0.1 | 3.125 | 0.1 | 3.125 | 0.195 | 3.125 | 0.1 | 0.78 | 0.1 | 0.39 | 0.195 | 3.125 | 0.195 | 1.56 |
| 22 | Ilex rotunda Thunb. | 0.78 | 3.125 | 1.56 | 25 | 1.56 | > 25 | 1.56 | 6.25 | 1.56 | 12.5 | 0.78 | 12.5 | 0.78 | 12.5 |
| 51 | Inula japonica Thunb. | 3.125 | 6.25 | 1.56 | > 25 | 3.125 | 25 | 3.125 | > 25 | 3.125 | 6.25 | 1.56 | 6.25 | 3.125 | 6.25 |
| 58 | Leontice kiangnanensis P.L.Chiu | 0.78 | 1.56 | 0.78 | 25 | 0.78 | > 25 | 0.78 | 3.125 | 6.25 | 25 | 0.78 | 12.5 | 0.78 | 3.125 |
| 61 | Oroxylum indicum Vent. | 0.39 | 1.56 | 0.39 | 6.25 | 0.78 | 25 | 0.78 | 1.56 | 0.39 | 0.78 | 1.56 | 3.125 | 1.56 | 3.125 |
| 65 | Isatis tinctoria L. | 3.125 | 25 | 3.125 | > 25 | 6.25 | > 25 | 6.25 | 12.5 | 12.5 | 12.5 | 6.25 | > 25 | 12.5 | > 25 |
| 81 | Terminalia chebula Retz. | 0.195 | > 25 | 0.78 | > 25 | 0.39 | > 25 | 0.78 | 25 | 0.78 | 25 | 0.78 | 25 | 0.39 | 25 |
| 96 | Speranskia tuberculata Baill. | 0.78 | 25 | 0.78 | > 25 | 0.78 | 12.5 | 0.78 | 12.5 | 0.78 | 12.5 | 1.56 | 12.5 | 0.78 | 12.5 |
| 97 | Acacia catechu (L.f.) Willd. | 0.195 | 3.125 | 0.39 | 6.25 | 0.195 | 6.25 | 0.78 | 0.78 | 0.78 | 1.56 | 0.195 | 0.78 | 0.195 | 1.56 |
| 103 | Dalbergia odorifera T.C.Chen | 0.39 | 3.125 | 0.39 | 12.5 | 0.39 | 6.25 | 0.39 | 3.125 | 0.39 | 6.25 | 0.39 | 0.78 | 0.39 | 6.25 |
| 112 | Quercus infectoria Oliv. | 0.1 | 12.5 | 0.195 | 25 | 0.195 | 6.25 | 0.195 | 12.5 | 0.19 | 1.56 | 0.195 | 1.56 | 0.195 | 12.5 |
| 115 | Spatholobus suberectus Dunn | 0.195 | 3.125 | 1.56 | > 25 | 0.78 | 6.25 | 0.39 | 6.25 | 0.78 | 3.125 | 0.78 | 0.78 | 0.78 | 12.5 |
| 132 | Rabdosia rubescens (Hemsl.) H.Hara | 1.56 | 12.5 | 1.56 | > 25 | 1.56 | 12.5 | 1.56 | 6.25 | 1.56 | 3.125 | 0.78 | 1.56 | 1.56 | 12.5 |
| 133 | Salvia miltiorrhiza Bunge | 0.39 | 3.125 | 1.56 | 25 | 3.125 | 12.5 | 1.56 | 6.25 | 0.78 | 3.125 | 3.125 | 6.25 | 3.125 | 6.25 |
| 168 | Fraxinus fallax Lingelsh. | 1.56 | > 25 | 1.56 | > 25 | 1.56 | 25 | 3.125 | 12.5 | 1.56 | 12.5 | 3.125 | 12.5 | 3.125 | 25 |
| 200 | Coptis chinensis Franch. | 0.39 | 1.56 | 0.195 | 25 | 0.39 | 12.5 | 0.39 | 1.25 | 0.39 | 0.78 | 0.195 | 1.56 | 0.195 | 0.78 |
| 202 | Agrimonia pilosa Ledeb. | 0.1 | 1.56 | 0.1 | 6.25 | 0.195 | 1.56 | 0.78 | 3.125 | 0.39 | 1.56 | 0.195 | 6.25 | 0.1 | 1.56 |
| 217 | Phellodendron chinense C.K. Schneid. | 0.78 | 3.125 | 0.78 | 12.5 | 0.39 | 1.56 | 0.78 | 1.56 | 0.78 | 0.78 | 0.195 | 3.125 | 0.39 | 1.56 |
| Ampicillin (μg/mL) | 0.05 | >25 | 6.25 | > 25 | >25 | NA 1 | >25 | NA | >25 | NA | 3.125 | >25 | 0.1 | >25 | |
| Oxacillin (μg/mL) | 0.195 | > 25 | 0.39 | > 25 | 0.39 | > 25 | 0.39 | 25 | 0.195 | 12.5 | 0.195 | > 25 | 0.195 | 25 | |
18 selected TCMP extracts with the highest DIZ values (DIZ ≥ 20 mm) were subjected to investigations of their MIC and MBC against one reference (ATCC 25923), one erythromycin-resistant (SJTUF 20827) and five multidrug-resistant (SJTUF 20745, SJTUF 20746, SJTUF 20758, SJTUF 20978 and SJTUF 20991) S. aureus strains (n = 3). Ampicillin and Oxacillin were used as positive controls. 1 NA, not applicable.