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. 2019 Dec 31;8(1):11. doi: 10.3390/vaccines8010011

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Splenic cytokine profile in immunized mice. BALB/c mice were orally immunized with one single dose of either free OMVs Escherichia coli F4 (F4), free OMVs E. coli F18 (F18) or OMVs encapsulated into nanoparticles (NP-F4, NP-F18) (n = 6). At Day 28 post-immunization, mice were sacrificed and spleen cells stimulated in vitro with PBS (light grey columns), F4 OMVs (grey columns) or F18 OMVs (black columns). Control non-immunized mice (NoI) were also included. The graphs show the levels of released cytokines from the primed splenocytes. p values of < 0.05 between OMVs encapsulated into nanoparticles and homologous free OMVs were considered as statistically significant (*).