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. 2019 Dec 31;8(1):11. doi: 10.3390/vaccines8010011

Figure 4.

Figure 4

OMV-specific antibodies in colostrum and offspring piglets of immunized sows. Groups of eight-week pregnant sows were immunized orally with the nanoparticle based vaccine, and compared with a commercial vaccine (Suiseng®) that was administered intramuscularly. Nanoparticles contained OMVs from F4 and F18 strains. Two different doses were used: NPI (50 mg OMV) and NPII (100 mg OMV). The first dose of nanoparticles was administered to the sows between the 7th and 8th week of gestation. The second dose was administered between the 13th and 14th week of gestation. A control group of non-immunized sows were also included. OMV-specific antibody profile (IgG, IgA or IgM) was measured the day of labor in colostrum of sows. A control group of non-immunized sows was also included. An OMV-specific antibody profile (IgG, IgA or IgM) was also measured one week after labor in serum of piglets. Data are expressed as the mean OD405 nm ± SD at the indicated dilutions. p values of <0.05 between intervention and control groups were considered as statistically significant (*).