Table 2.
Serum Hemagglutination Inhibition and Neutralizing antibody levels and percent of subjects seroconverting after the first and second doses of H3N2v vaccine.
| Antibody Titers | Measured Metric | Day 0 (Pre-Vaccination) |
Day 8 (Post Vaccination 1) |
Day 21 (Post Vaccination 1, Immediately Pre-Vaccination 2) |
Day 29 (Day 8 Post Vaccination 2) |
Day 42 (Day 21 Post Vaccination 2) |
|---|---|---|---|---|---|---|
| Hemagglutination Inhibition (HAI) | Geometric Mean Titer (95% CI) | 27.5 (19.8, 38.3) | 91.9 (59.1, 142.8) | 117.9 (79.8, 174.2) | 126.4 (81.7, 195.6) | 135.5 (86.2, 213.0) |
| Seroconversion 1—n (%) | NA | 13 (52.0) | 14 (56.0) | 13 (52.0) | 13 (52.0) | |
| Neutralizing Antibody (Neut) | Geometric Mean Titer (95% CI) | 28.5 (16.0, 50.7) | 178.0 (103.6, 306.0) | 285.5 (162.2, 502.5) | 276.9 (157.8, 486.1) | 258.3 (149.7, 445.6) |
| Seroconversion 1—n (%) | NA | 12 (48.0) | 13 (52.0) | 13 (52.0) | 13 (52.0) |
1 Seroconversion was defined as HAI or Neut 4-fold increase from baseline to a titer ≥ 40.