Table 6.

Correlation of post vaccination CD4+ T cell responses with serum antibody responses.

Measured Metrics	Hemagglutination Inhibition Titer (p-Value)				Neutralizing Antibody Titer (p-Value)
CD154, IFN-γ, IL-2 or IL-21 expression CD4+ T Cells change from baseline (Day 0)	Day 8	Day 21	Day 29	Day 42	Day 8	Day 21	Day 29	Day 42
Day 8–Day 0	0.582 (0.002)	0.649 (<0.001)	0.526 (0.007)	0.265 (0.200)	0.621 (<0.001)	0.859 (<0.001)	0.870 (<0.001)	0.602 (<0.001)
Day 21–Day 0		0.667 (<0.001)	0.542 (0.005)	0.295 (0.153)		0.865 (<0.001)	0.874 (<0.001)	0.618 (<0.001)
Day 29–Day 0			0.525 (0.008)	0.279 (0.187)			0.909 (<0.001)	0.687 (<0.001)
Day 42–Day 0				0.280 (0.196)				0.679 (<0.001)