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. 2020 Mar 23;8(1):143. doi: 10.3390/vaccines8010143

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic example of the layered consensus used for H7 COBRA design. The viruses were divided into four groups (H7N9, H7N7, H7N3, and H7N2) based on different HA/NA combinations. H7N9 viruses were further subdivided into five epidemic waves. Primary consensus amino acid sequences were derived from the three groups (H7N7, H7N3, and H7N2) and five subgroups (referred to five wave H7N9). CH7-26 was generated based on the primary consensus sequences of H7N7, H7N3, and H7N2. CH7-24 was obtained from the primary consensus sequences of five wave H7N9. Second consensus amino acid sequences were derived from primary sequences. Then, CH7-22 was designed based on all secondary consensus sequences. CH7-28 was derived from CH7-26 sequences by introducing S136N and A143V mutations. The green arrow refers to the secondary consensus, which was generated by alignment of the primary consensus of H7N3 and H7N2.