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. 2020 Feb 12;8(1):83. doi: 10.3390/vaccines8010083

Figure 5.

Figure 5

Effects of IL-17A DNA vaccine in MRL/lpr mice; (a) Female MRL/lpr mice were immunized with pcDNA3.1-HBc-IL17A1 (IL-17A1) or saline via intramuscular administration using an electroporator three times at 2-week intervals. Booster immunization was performed 13 weeks after three vaccinations. Antibody titers of vaccinated MRL/lpr mice were measured 6 weeks after first vaccination (12 weeks old), and mice were sacrificed 18 weeks after first vaccination (24 weeks old). (b) Antibody titers from vaccinated 12-week-old MRL/lpr mice were measured (n = 8). (c) Time course of IL-17A DNA vaccination for survival experiments. Kaplan–Meier curve of time to survival rate, log rank p = 0.10 between HBc-IL-17A group and nonimmunization group (saline). The arrows indicate vaccination. (●): IL-17A vaccine group (n = 6); (▲): saline group (n = 8); The arrows indicate the intramuscular administration of Il-17A vaccine or Saline using an electroporator.