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. 2019 Dec 31;8(1):12. doi: 10.3390/vaccines8010012

Table 1.

Sample sizes by study type.

Study Type n Minimum Sample Size Median Maximum
RCT (no phase specified) 27 64 550 2503
RCT phase 2 3 200 2499 2648
RCT phase 2b 1 460
RCT phase 3 9 312 802 1620
RCT phase 3b 2 716 730 744
RCT phase 4 3 376 1341 1504
Case Control 1 590
Prospective Observational Cohort 1 530
Retrospective Observational Cohort 1 36,844
Surveillance report 1 128,297
Case Reports 1 833