Table 2.
Cross neutralization of flaviviruses by subjects with and without ZIKV exposure. Data denotes average neutralization ± standard deviation.
| Patient ID | Virus | ||||||
|---|---|---|---|---|---|---|---|
| DENV 1 | DENV 2 | DENV 3 | DENV 4 | YFV | WNV | JEV | |
| ZIKV Exposure with Unknown Exposure History | |||||||
| 50616 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
| 50620 | 0 ± 0 | 0 ± 0 | 99.5 ± 0.7 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 67 ± 0.7 |
| 50622 | 0 ± 0 | 0 ± 0 | 99.5 ± 0.7 | 0 ± 0 | 97 ± 0.7 | 0 ± 0 | 61 ± 2.1 |
| 125 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
| 88 | 0 ± 0 | 100 ± 0 | 99.5 ± 0.7 | 0 ± 0 | 92 ± 1.4 | 0 ± 0 | 13 ± 3.5 |
| Flavivirus Naïve SPF Sheep with ZIKV Infection | |||||||
| 4155 | 0 ± 0 | 100 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 79 ± 0.7 |
| 4158 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 97 ± 0.7 | 0 ± 0 | 78 ± 5.6 |
| 4072 | 0 ± 0 | 78 ± 1.4 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 82 ± 0 |
| 4171 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 0 ± 0 | 100 ± 0 | 0 ± 0 | 0 ± 0 |
| ZIKV Naïve with Unknown Flavivirus Exposure | |||||||
| 315 | 100 ± 0 | 0 ± 0 | 100 ± 0 | 0 ± 0 | 86.6 ± 1.4 | 85.3 ± 4.2 | 93.2 ± 2.8 |
| 070 | 100 ± 0 | 100 ± 0 | 0 ± 0 | 0 ± 0 | 96.6 ± 1.4 | 47 ± 9.9 | 0 ± 0 |
| 200 | 100 ± 0 | 100 ± 0 | 100 ± 0 | 100 ± 0 | 55 ± 6.3 | 0 ± 0 | 92.2 |
| 252 | 98.1 ± 2.5 | 100 ± 0 | 100 ± 0 | 100 ± 0 | 0 ± 0 | 58.5 ± 1.4 | 91.2 |