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. 2020 Feb 24;8(1):100. doi: 10.3390/vaccines8010100

Table 1.

List of the top ten Gene Ontology Biological Processes over-represented in the genes that are up-regulated in both the infected KO-1 and KO-2 cells.

Term Gene Symbol Benjamini (p-Value)
GO:0006955 Immune response CCL26, CXCL2, CXCL5, CXCL8, CD70, CD74, SAMHD1, TNFRSF1B, TNFRSF21, B2M, CTSS, CIITA, C1R, C3, GBP2, IFITM2, IL1RAP, IL7R, HLA-C, PDCD1LG2, TLR4, TRIM22, TNFSF10, TNFSF13B, TNFSF14, TNFSF9 0.017
GO:0001666 Response to hypoxia CD24, CD38, CASP1, DPP4, EGLN1, EDNRA, HIF1A, LOXL2, MMP2, MUC1, PLAT, PLOD2, SLC2A8, SOD2, TGFBR2 0.031
GO:0051607 Defense response to virus MX2, SAMHD1, APOBEC3G, GBP1, GBP3, IFI16, IFI44L, IFIT1, IFITM1, IFITM2, IL33, SERINC5, TLR3, TRIM22 0.055
GO:0006954 Inflammatory response CCL17, CCL26, CXCL2, CXCL5, CXCL8, SMAD1, TNFRSF1B, TNFRSF21, AOX1, CHST2, CASP4, CIITA, C3, ITGB2, IFI16, IL1RAP, NR1H4, PTX3, RPS6KA5, THEMIS2, TLR3, TLR4 0.060
GO:0060333 Interferon-gamma-mediated signaling pathway IFI30, B2M, CIITA, GBP1, GBP2, IFNGR1, HLA-C, MT2A, TRIM22 0.069
GO:0007155 Cell adhesion ADAM12, CD24, EDIL3, EPHA4, KIAA1462, KITLG, CDH2, CDH6, CEACAM1, COL4A6, COL5A1, EFNB2, FAP, FN1, LGALS3BP, ISLR, IGFBP7, ITGB2, LSAMP, LOXL2, RGMB, SCN1B, TNC, THEMIS2 0.084
GO:0060337 Type I interferon signaling pathway MX2, SAMHD1, XAF1, GBP2, IFIT1, IFITM1, IFITM2, HLA-C 0.15
GO:0002237 Response to molecule of bacterial origin CXCL2, CXCL8, CD24, MALT1 0.20
GO:0045766 Positive regulation of angiogenesis CXCL8, GATA2, GATA6, WNT5A, CCBE1, C3, HIF1A, ITGB2, TGFBR2, TWIST1 0.22
GO: 0040037 Negative regulation of fibroblast growth, factor receptor signaling pathway WNT4, WNT5A, SPRY1, SULF2 0.22