Table 2.
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways over-represented in the genes that are up-regulated in both the infected KO-1 and KO-2 cells.
| Term | Gene Symbol | Benjamini (p-Value) |
|---|---|---|
| hsa04060 Cytokine-cytokine receptor interaction | CCL17, CCL26, CXCL2, CXCL5, CXCL8, CD70, TNFRSF19, TNFRSF1B, TNFRSF21, IFNGR1, IL1RAP, IL7R, LIFR, TGFBR2, TNFSF10, TNFSF13B, TNFSF14, TNFSF9 | 0.015 |
| hsa05133 Pertussis | CXCL5, CXCL8, CASP1, C1R, C1S, C3, C4BPA, ITGB2, TLR4 | 0.041 |
| hsa05134 Legionellosis | CXCL2, CXCL8, CASP1, C3, EEF1A2, ITGB2, TLR4 | 0.11 |
| hsa00760 Nicotinate and nicotinamide metabolism | NT5C3A, CD38, AOX1, NNMT, NNT | 0.21 |
| hsa04610 Complement and coagulation cascades | C1R, C1S, C3, C4BPA, CFB, CFI, PLAT | 0.22 |
| hsa05150 Staphylococcus aureus infection | C1R, C1S, C3, CFB, CFI, ITGB2 | 0.27 |
| hsa05152 Tuberculosis | CD74, MALT1, CTSS, CIITA, C3, EEA1, ITGB2, IFNGR1, TLR4, VDR | 0.55 |
| hsa04145 Phagosome | CTSS, C1R, C3, EEA1, ITGB2, HLA-C, TLR4, TUBA1A, TUBB3 | 0.51 |
| hsa04612 Antigen processing and presentation | CD74, IFI30, B2M, CTSS, CIITA, HLA-C | 0.55 |
| hsa05146 Amoebiasis | CXCL8, COL4A5, COL4A6, COL5A1, FN1, ITGB2, TLR4 | 0.58 |