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Macrophage polarization status. Mean immunohistochemistry score (IHC-score) in sacculus rotundus (SR) and vermiform appendix (VA) in the infected controls (IC), experimental intradermal vaccine (VID), experimental oral vaccine (VOR), and control vaccine (VC) animals for (a) IFNγ; (b) TNFα; (c) CD163; (d) calprotectin. Error bars represent the Confidence Interval of 95%. * p < 0.05; ** p < 0.01; *** p < 0.001.
