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. 2020 Feb 6;8(1):72. doi: 10.3390/vaccines8010072

Figure 6.

Figure 6

Cells treated with a statin drug and Th1 cytokines demonstrate enhanced activation of caspase 3/7. SK-BR-3, HCC1419, MDA-MB-231, and MDA-MB-468 human breast cancer cell lines were cultured with no additives (No Tx), treated with recombinant Th1 cytokines (TNF-α and IFN-γ, 10 ng/mL each), a statin drug (A) Simvastatin or (B) Fluvastatin (1 µM MDA-MB-231; 10 µM remaining cell lines), or the combination of Th1 cytokines and a statin drug (A) “Simva + Cyto” or (B) “Fluva + Cyto” and stained with CellEvent™ fluorescent caspase substrate. The experiment was repeated at least three times; the displayed flow cytometric results are from one representative experiment. The percentage of stained events, as well as the geometric mean channel fluorescence (in parentheses), is annotated on each histogram.