Table 1.

Clinical, serological (virus neutralisation test (VNT) titre against challenge strain A/IRN/22/2015 at the day of challenge) and virological results in the 8-day period following challenge, in the full dose protection test in cattle vaccinated with A₂₂/IRQ/64 and A/MAY/97 vaccine, and unvaccinated animals challenged with A/IRN/22/2015. For foot lesions a + indicates that foot lesions were present, a D indicates that a doubtful foot lesion was observed and a - indicates that no foot lesions were observed.

	Cow Number	Foot Lesions	VNT Titre at Day of Challenge 1	Duration Virus Detection (Days)			Maximum Titre (Log PFU/mL)			Duration Genome Detection (Days)
				Serum 2	Nose 3	Mouth 4	Serum 2	Nose 3	Mouth 4	Serum 2	Nose 3	Mouth 4
Vaccine A22/IRQ/64	1227	-	1.2	0	0	6	0.0	0.0	6.1	2	5	6
	1228	+	1.05	0	2	5	0.0	2.6	6.8	3	8	8
	1229	+	1.5	0	2	6	0.0	2.1	7.4	2	7	8
	1230	+	1.5	0	2	4	0.0	1.2	5.5	1	7	8
	1231	+	1.05	0	5	6	0.0	3.3	5.2	2	8	8
	1232	-	1.2	0	2	6	0.0	1.7	7.9	2	7	7
	1233	+	0.6	0	4	5	0.0	2.6	6.7	4	7	8
Vaccine A/MAY/97	1234	D	1.95	0	2	5	0.0	1.2	4.4	0	6	7
	1235	-	1.95	0	3	6	0.0	1.4	5.9	0	6	8
	1236	-	2.1	0	1	6	0.0	0.4	4.9	0	6	7
	1237	D	2.1	0	1	6	0.0	0.4	6.6	2	7	8
	1238	-	2.1	0	1	5	0.0	0.4	4.5	0	3	5
	1239	-	1.5	0	2	6	0.0	1.7	6.7	0	6	8
	1240	-	1.8	0	4	5	0.0	1.8	7.5	0	5	8
Control	1241	D	<0.6	3	4	8	3.3	3.5	4.5	5	8	8
	1242	+	<0.6	3	6	8	3.4	3.7	5.0	4	8	8
	1243	+	<0.6	3	5	8	3.8	3.8	4.7	5	7	8

¹ VNT titres at 0 DPC from supplement Table S1c, ² Serum data from supplement Table S2, ³ Nose swab data from supplement Table S3, ⁴ Mouth swab data from supplement Table S4.