Table 2.

Clinical, serological (VNT titre against challenge strain A/IRN/22/2015 at the day of challenge) and virological results in the 8-day period following challenge, in the potency test using A/MAY/97 vaccine. For foot lesions a + indicates that foot lesions were present, a - indicates that no foot lesions were observed.

	Cow Number	Foot Lesions	VNT Titre at Day of Challenge 1	Duration Virus Detection (Days)			Maximum Titre (log PFU/mL)			Duration Genome Detection (Days)
				Serum 2	Nose 3	Mouth 4	Serum 6	Nose 7	Mouth 8	Serum 6	Nose 7	Mouth 8
Full dose	1566	-	1.2	0	5	6	0.0	2.7	7.7	1	6	8
	1567	-	1.5	0	3	7	0.0	1.1	7.4	1	7	7
	1568	-	1.2	0	3	4	0.0	1.9	5.2	0	6	7
	1569	-	1.65	0	1	6	0.0	0.7	8.3	1	3	8
	1570	-	1.35	0	1	5	0.0	0.9	7.6	2	4	7
1/3 dose	1571	-	1.35	0	2	5	0.0	0.9	8.0	1	7	8
	1572	-	1.05	0	2	5	0.0	2.6	7.9	2	7	8
	1573	-	1.65	0	0	5	0.0	0.0	5.0	0	3	6
	1574	-	0.75	0	2	5	0.0	3.3	7.1	1	5	6
	1575	+	0.6	0	4	7	0.0	1.0	7.1	1	8	8
1/9 dose	1576	+	0.9	0	2	6	0.0	0.9	6.2	4	6	8
	1577	-	1.2	0	1	7	0.0	0.4	7.5	2	4	8
	1578	-	0.75	0	3	5	0.0	1.9	6.4	0	4	8
	1579	+	0.3	0	5	5	0.0	3.2	7.0	4	7	8
	1580	+	0.3	0	3	6	0.0	3.6	7.4	4	5	8
Control	1581 *	+	<0.3	3	6	7	4.8	4.7	6.7	4	7	7
	1582	+	<0.3	3	6	6	3.9	3.9	7.1	5	8	8
	1583	+	<0.3	3	5	7	4.7	3.7	4.9	4	6	8

* Cow 1581 died 7 days post challenge. A high concentration of FMD genome was detected in the cardiac muscle and histology revealed infiltration of mononuclear cells and disintegration of muscle tissue. ¹ VNT titres at 0 DPC from supplement Table S5b, ² Serum data from supplement Table S6, ³ Nose swab data from supplement Table S7, ⁴ Mouth swab data from supplement Table S8.