FIG 5.
Histopathology in immunized mice challenged with MERS-CoV. hDPP4 KI mice were intranasally immunized with 104 PFU PIV5-MERS-S or PIV5-GFP. Four weeks after immunization, the mice were intranasally infected with 105 PFU MERSMA6.1.2. (A) Representative images of H&E-stained lung sections from PIV5-MERS-S- or PIV5-GFP-immunized hDPP4 KI mice at indicated days after MERSMA6.1.2 challenge. Note the cellular infiltration (black arrows) and the hyaline membranes (red arrows). (B) Summary scores for disease in the lung sections. n = 3 to 5 mice/group. * denotes P < 0.05, Mann-Whitney test; N/A denotes not applicable.