Table 3.
Univariate Cox regression analysis of survival among patients with clear cell carcinoma of the uterine cervix (N = 50).
| Variables | Disease-free survival | Overall survival | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age | ||||||
| <40 years | 1.00 | 1.00 | ||||
| ≥40 years | 0.67 | 0.15–2.98 | 0.596 | 0.67 | 0.15–3.00 | 0.601 |
| Stage | ||||||
| I | 1.00 | 1.00 | ||||
| II | 2.81 | 0.34–23.40 | 0.340 | 3.01 | 0.36–25.10 | 0.308 |
| Tumour size | ||||||
| <4 cm | 1.00 | 1.00 | ||||
| ≥4 cm | 4.62 | 0.89–23.95 | 0.068 | 5.67 | 1.09–29.55 | 0.039 |
| Parametrial involvement | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 3.88 | 0.75–20.05 | 0.106 | 3.80 | 0.74–19.64 | 0.111 |
| LVSI | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 1.20 | 0.14–9.95 | 0.869 | 1.10 | 0.13–9.17 | 0.929 |
| Depth of stromal invasion | ||||||
| <1/2 | 1.00 | 1.00 | ||||
| ≥1/2 | 0.41 | 0.08–2.10 | 0.281 | 0.42 | 0.08–2.16 | 0.299 |
| Lymph node metastasis | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 0.04 | 0.00–948.3 | 0.533 | 0.04 | 0.00–1492 | 0.553 |
| B7-H3 | ||||||
| Negative | 1.00 | 1.00 | ||||
| Positive | 0.04 | 0.00–179.5 | 0.447 | 0.04 | 0.00–138.9 | 0.431 |
| B7-H4 | ||||||
| Negative | 1.00 | 1.00 | ||||
| Positive | 0.35 | 0.04–2.88 | 0.326 | 0.38 | 0.05–3.20 | 0.376 |
| PD-L1 | ||||||
| Negative | 1.00 | 1.00 | ||||
| Positive | 1.40 | 0.27–7.20 | 0.691 | 1.25 | 0.24–6.44 | 0.792 |
| VISTA | ||||||
| Negative | 1.00 | 1.00 | ||||
| Positive | 1.23 | 0.24–6.38 | 0.802 | 0.82 | 0.16–4.23 | 0.812 |
LVSI: lymphovascular space invasion; PD-L1: programmed cell death-ligand 1; VISTA: V-domain Ig suppressor of T cell activation; HR: hazard ratio; CI: confidence interval.