Table 1.
Selection of RNA virus B6RA/BNP-affinity protein sequence motifs RX(D/E)
| Virus | Virus Family |
Strain | Virus Protein | B6RA/BNP |
|---|---|---|---|---|
| Subfamily |
Target Sequence | |||
| Genus | ||||
| Polio type 1 | Picornaviridae | Mahoney, Sabin | 3D | 2006-FGDRVDYI-2013 |
| Enterovirus | RNA-dependent | |||
| RNA | ||||
| Polymerase | ||||
| Polio type 2 | Picornaviridae | Lansing, P712 | 3D | 2004-FGDRVDYI-2011 |
| Enterovirus | RNA-dependent | |||
| RNA | ||||
| Polymerase | ||||
| Polio type 3 | Picornaviridae | Sabin vaccine | 3D | 2003-FGDRVDYI-2010 |
| Enterovirus | P3/Leon/37, | RNA-dependent | ||
| Sabin vaccine | RNA | |||
| P3/Leon/12a[1]b, | Polymerase | |||
| 23127 | ||||
| Polio type 1 | Picornaviridae | Mahoney, Sabin | 3D | 2125-FFRADEKYPFLI-2136 |
| Enterovirus | RNA-dependent | |||
| RNA | ||||
| Polymerase | ||||
| Polio type 2 | Picornaviridae | Lansing | 3D | 2123-FFRADEKYPFLV-2134 |
| Enterovirus | RNA-dependent | |||
| RNA | ||||
| Polymerase | ||||
| Polio type 3 | Picornaviridae | Sabin vaccine | 3D | 2122-FFRADEKYPFLI-2133 |
| Enterovirus | P3/Leon/37, | RNA-dependent | ||
| Sabin vaccine | RNA | |||
| P3/Leon/12a[1]b, | Polymerase | |||
| 23127 | ||||
| Human Coxsackie A9 | Picornaviridae | Griggs | 3D | 2113-FLKRYFRADEQYPFLV-2128 |
| Enterovirus | RNA-dependent | |||
| RNA | ||||
| Polymerase | ||||
| Human Coxsackie A24 | Picornaviridae | EH24/70 | 3D | 2126-FLKRFFRADEKYPFLV-2141 |
| Enterovirus | RNA-dependent | |||
| RNA | ||||
| Polymerase | ||||
| Human Coxsackie B1 | Picornaviridae | Japan | 3D | 2094-FLKRYFRADEQYPFLV-2109 |
| Enterovirus | RNA-dependent | |||
| RNA | ||||
| Polymerase | ||||
| Human Coxsackie B3 | Picornaviridae | Nancy | 3D | 2097-FLKRYFRADEQYPFLV-2112 |
| Enterovirus | RNA-dependent | |||
| RNA | ||||
| Polymerase | ||||
| Human Coxsackie B4 | Picornaviridae | E2, JVB / Benschoten / New York/51 | 3D | 2095-FLKRYFRADEQYPFLV-2110 |
| Enterovirus | RNA-dependent | |||
| RNA | ||||
| Polymerase | ||||
| Human Coxsackie B5 | Picornaviridae | 1954/UK/85 | 3D | 2097-FLKRYFRADEQYPFLV-2112 |
| Enterovirus | RNA-dependent | |||
| RNA | ||||
| Polymerase | ||||
| Human Severe Acute Respiratory Syndrome (SARS) Corona | CoronaviridaeCoronavirus | Tor2, CUHK-W1, Urbani | Putative NSP9 in ORF1ab Polyprotein RNA-dependent RNA Polymerase | 4470-FFKFRVDGDMVP-4481 |
| Human Severe Acute Respiratory Syndrome (SARS) Corona | CoronaviridaeCoronavirus | Tor2, CUHK-W1, Urbani | Putative NSP10 in ORF1ab Polyprotein Metal-binding NTPase Helicase | 5634-IIPARARVECFDKFKV-5649 |
| Rabies | Rhabdoviridae | Pasteur / PV, SAD B19 | L | 150-VLSCLERVDYDNAF-163 |
| Lyssavirus | RNA-directed | 659-WIYYSDRSDLIGL-671 | ||
| RNA | ||||
| Polymerase | ||||
| 5‘-RNA | ||||
| Capping | ||||
| Poly— | ||||
| Adenylation | ||||
| Rabies | Rhabdoviridae Lyssavirus | Pasteur / PV, SAD B19, ERA, Street, HEP-FLURY, vnukovo-32 | G Spike Membrane Glycoprotein Precursor | 276-LVNLHDFRSDEIEHLV-291 |
| Human | Paramyxoviridae | NIH 47885, | HN | 272-PKVDERSDYASS-283 |
| Parainfluenza | Paramyxovirinae | Wash/1511/73, | Hemagglutinin— | |
| type 3 | Respirovirus | Aus/124854/74, | Neuraminidase | |
| Wash/641/79, | ||||
| Tex/545/80, | ||||
| Tex/9305/82, | ||||
| Tex/12677/83 | ||||
| Measles | Paramyxoviridae Paramyxovirinae Morbillivirus | Edmonston, edmonston-zagreb, Halle, edmonston b, philadelphia-26, leningrad-16, Yamagata-1 | F Fusion Membrane Glycoprotein Precursor | 437-YPDAVYLHRIDLGPPISL-454450-PPISLERLDVGTNLG-464 |
| Measles | Paramyxoviridae Paramyxovirinae Morbillivirus | Edmonston, Rubeovax, Moraten, AIK-C, HU2, SE, Schwarz vaccine, CL, TT | M Viral Matrix Protein | 186-VAFNLLVTLRIDKAIGP-202 |
| Human Respiratory Syncytial A | Paramyxoviridae Pneumovirinae Pneumovirus | A2 | L RNA-directed RNA Polymerase Protein Kinase | 917-YRGESLLCSLIF-928 |
| Human Respiratory Syncytial A / B | Paramyxoviridae Pneumovirinae Pneumovirus | A2, Long, subgroup B/strain 18537 | P Phosphoprotein L/N-binding mRNA 5‘-Capping and Polyadenylation | 131-ITARLDRIDEKLSEIL-146 |
| Marburg | Filoviridae | Musoke, Popp | NP | 558-PPPPLYAQEKRQDPIQHP-575 |
| Filovirus | Nucleocapsid | |||
| Marburg virus | Major | |||
| Nucleoprotein | ||||
| Marburg | Filoviridae | Musoke | L | 1169-LLPYDCKELRLEGS-1182 |
| Filovirus | RNA-directed | 1763-ITKHDQRCEREESSP-1777 | ||
| Marburg virus | RNA | |||
| Polymerase | ||||
| mRNA | ||||
| 5′-Capping and | ||||
| Polyadenylation | ||||
| Marburg | Filoviridae | Musoke, Popp | M/VP40 | 262-MMKKRGENSPVVYF-275 |
| Filovirus | Viral Matrix Protein | |||
| Marburg virus | ||||
| Human Hepatitis A | Picornaviridae Hepatovirus | HM-175 wild type, 18F, 24A, 43C, LA, MBB | 2C Initiation of RNA Synthesis | 1216-AMVTRCEPVVCYL-1228 |
| Yellow Fever | Flaviviridae | 17D, | NS5 | 2638-IHRLEPVKCDTLL-2650 |
| Flavivirus | Pasteur | RNA-dependent | 3148-SVLTRLEAWLT-3158 | |
| 17D-204 | RNA | |||
| Polymerase | ||||
| Dengue type 1 | Flaviviridae | Singapore | NS3 | 2011-LMRRGDLPVWLSY-2023 |
| Flavivirus | S275/90 | Protease | ||
| NTP-Binding | ||||
| Helicase | ||||
| Dengue type 2 | Flaviviridae | Jamaica, 16681, | NS3 | 2011-LMRRGDLPVWLAY-2023 |
| Flavivirus | PR159/S1, | Protease | ||
| 16681-PDK53, | NTP-Binding | |||
| New Guinea-C, Tonga 1974 | Helicase | |||
| Dengue type 3 | Flaviviridae | — | NS3 | 2010-LMRRGDLPVWLAH-2022 |
| Flavivirus | Protease | |||
| NTP-Binding | ||||
| Helicase | ||||
| Dengue type 4 | Flaviviridae | — | NS3 | 2009-LMRRGDLPVWLSY-2021 |
| Flavivirus | Protease | |||
| NTP-Binding | ||||
| Helicase | ||||
| West Nile | Flaviviridae | WN-NY99 | E/V3 | 370-AHNDKRADPAFVC-382 |
| Flavivirus | Membrane— | |||
| Associated Viral Envelope | ||||
| Glycoprotein | ||||
| Kunjin | Flaviviridae | MRM61C | E | 370-AHNDKRADPSFVC-382 |
| Flavivirus | Membrane— | |||
| Associated Viral Envelope | ||||
| Glycoprotein | ||||
| St. Louis | Flaviviridae | MS1-7 | E | 368-AHNTKRSDPTFVC-380 |
| Encephalitis | Flavivirus | Major | ||
| Envelope | ||||
| Protein | ||||
| Hepatitis C | Flaviviridae Hepacivirus | 1, BK, J, Taiwan, Japanese, H77, HCV-1, H, JK1, JK5, HC-JT | E2/NS1 Glycosylated Membrane Protein | 646-WTRGERCDLEDRDR-659 |
| Rubella | Togaviridae | Therien | NSP1-2 | 494-CACAPRCDVPRERPSAP-510 |
| Rubivirus | Nonstructural | |||
| Polyprotein | ||||
| 5‘-Cap | ||||
| Methyltransferase | ||||
| Zn2+-Cysteine | ||||
| Protease | ||||
| Rubella | Togaviridae Rubivirus | Therien, HPV77 vaccine, RA27/3 vaccine | C Structural Polyprotein Nucleocapsid Protein | 165-AVFYRVDLHFTNLGTPP-181 |
| Human Corona | Coronaviridae | 229E | S/E2 | 94-FVYFNGTGRGDCKGFSSDV-112 |
| Coronavirus | Surface Spike | 257-SVINRLRCDQLSFDVP-272 | ||
| Glycoprotein | 636-ALRNSARLESADVSEML-652 | |||
| Precursor | 1016-VTFVNISRSELQTIVP-1031 | |||
| Aminopeptidase N-binding | 1099-LVDLKWLNRVETYIKWP-1115 | |||
| Marburg | Filoviridae | Musoke, Popp | VP30 | 160-YLHRSEIGNWM-170 |
| Filovirus | Phosphorylated Nucleocapsid Protein | |||
| Marburg virus | ||||
| Marburg | Filoviridae | Musoke, Popp | VP24 | 197-FLVEVRRIDIEPCC-210 |
| Filovirus | Membrane-associated Structural Protein | |||
| Marburg virus | ||||
| Ebola | Filoviridae | Mayinga, | NP | 103-GFRFEVKKRDGV-114 |
| Filovirus | Zaire-95, | Nucleocapsid | 108-VKKRDGVKRLEELLPAV-124 | |
| Ebola virus | Gabon-94 | Major | ||
| Zaire | Nucleoprotein | |||
| Ebola | Filoviridae | Mayinga | P/VP35 | 292-PPVIHIRSRGDIPRAC-307 |
| Filovirus | Polymerase Complex Protein (Minor | |||
| Ebola virus | Nucleoprotein) | |||
| Zaire | ||||
| Borna Disease | BornaviridaeBornavirus | He/80, He/80/FR, V, V/FR, H1766, No/98, CRNP5, CRP3A, CRP3B | P/p23Nucleocapsid Phosphorylated P-Protein | 99-DISARIEAGF-108116-VETIQTAQRCDHSDSIR-132 |
| Borna Disease | BornaviridaeBornavirus | He/80, He/80/FR, V, V/FR, H1766, CRNP5, CRP3A, CRP3B | N/p40Nucleocapsid Nucleic Acid-bindingN-Protein | 100-YLSTPVTRGEQTVV-113339-YRRREISRGEDGAELS-354 |
| Hantaan | Bunyaviridae | 76-118, 84Fli, A16 | M Polyprotein | 420-VNFVCQRVDMDIVVYC-435 |
| Hantavirus | Segment/ | |||
| Glycosylated | ||||
| Membrane | ||||
| G1 Protein | ||||
| Hantaan | Bunyaviridae | R22 | M Polyprotein | 418-ISFICQRVDMDIIVYC-433 |
| Hantavirus | Segment/ | |||
| Glycosylated | ||||
| Membrane | ||||
| G1 Protein | ||||
| Lassa | Arenaviridae | Josiah | NP S Segment | 113-VIRTERPLSAGVYM-126 |
| Arenavirus | Major Structural | |||
| Old World | Nucleoprotein | |||
| Arenaviruses | Nucleocapsid | |||
| Component | ||||
| Lassa | Arenaviridae | GA391 Nigeria | NP S Segment | 113-VTRTERPLSSGVYM-126 |
| Arenavirus | Major Structural | |||
| Old World | Nucleoprotein | |||
| Arenaviruses | Nucleocapsid | |||
| Component | ||||
| Human Rota | Reoviridae | KU | VP4/VP5 | 336-FSVSRYEVIKENSYVYV-352 |
| group A | Rotavirus | Outer Layer | 482-PIMNSVTVRQDLERQL-497 | |
| Rotavirus A | Surface Protein | 733-YGITRIEALNLI-744 | ||
| Human | Hemagglutinin | 760-PIIRNRIEQLILQC-773 | ||
| Rotavirus A | Fusion Protein | |||
| Human Immunodeficiency | Retroviridae | HIV-1 Reference Genome, | TatTrans-activating Transcriptional | 1-MEPVDPRLEPW-11 |
| type 1 | Lentivirus | HTLV-III/LAV, HXB2, BRU, PV22, RF/HAT | RegulatoryProtein | 73-PTSQPRGDPTGP-84 |
| Human Immunodeficiency | Retroviridae | HXB3, BH10, Clone 12 | TatTrans-activating Transcriptional | 1-MEPVDPRLEPW-11 |
| type 1 | Lentivirus | Regulatory | 73-PTSQSRGDPTGP-84 | |
| Protein | ||||
| Human Immunodeficiency | Retroviridae | HIV-1 Reference Genome, | Vif (Sor) | 129-VSPRCEYQA-137 |
| type 1 | Lentivirus | HTLV-III/LAV, HXB2, BRU, PV22, RF/HAT, BH10, Clone 12 | Viral Infectivity FactorAccessoryProtein | |
| Human Immunodeficiency | Retroviridae | HIV-1 Reference Genome, | Nef/p27 | 13-WPTVRERMRRAEPAA-27 |
| type 1 | Lentivirus | HTLV-III/LAV, HXB2, BRU | Negative Factor | 100-LIHSQRRQDILDLWIY-115 |
| Anti-apoptotic Accessory | ||||
| Protein |