Table 1.
Differentially expressed genes between blue, green and red color phenotypes of Oophaga pumilio previously linked to coloration
| rank | gene | transcripts | q-val | expression-pattern | pigmentation role |
|---|---|---|---|---|---|
| 88 | dgat2 | 4 | 0.000 | GREEN > RED = BLUE | carotenoid metabolism |
| 102 | rdh16 | 4 | 0.000 | BLUE = GREEN > RED | carotenoid metabolism |
| 145 | scarb1 | 1 | 0.000 | RED > BLUE > GREEN | carotenoid metabolism |
| 371 | rdh10 | 2 | 0.000 | BLUE > RED = GREEN | carotenoid metabolism |
| 691 | bco2 | 6 | 0.002 | BLUE > RED = GREEN | carotenoid metabolism |
| 969 | dhrs3 | 1 | 0.005 | GREEN > RED = BLUE | carotenoid metabolism |
| 1124 | aldh1a1 | 7 | 0.008 | BLUE = GREEN > RED | carotenoid metabolism |
| 240 | adsl | 8 | 0.000 | GREEN > RED = BLUE | guanine synthesis in iridophores |
| 525 | psat1 | 4 | 0.001 | BLUE > RED = GREEN | guanine synthesis in iridophores |
| 1807 | gmps | 7 | 0.024 | RED = GREEN > BLUE | guanine synthesis in iridophores |
| 1871 | fh | 5 | 0.025 | RED > GREEN > BLUE | guanine synthesis in iridophores |
| 12 | camk2g | 6 | 0.000 | RED = GREEN > BLUE | melanin synthesis |
| 91 | gnai1 | 7 | 0.000 | RED > GREEN > BLUE | melanin synthesis |
| 98 | ctnnb1 | 13 | 0.000 | GREEN > RED = BLUE | melanin synthesis |
| 197 | raf1 | 8 | 0.000 | RED = GREEN > BLUE | melanin synthesis |
| 481 | wnt9a | 3 | 0.001 | RED > GREEN > BLUE | melanin synthesis |
| 521 | adcy6 | 4 | 0.001 | RED > GREEN > BLUE | melanin synthesis |
| 771 | wnt11 | 3 | 0.003 | BLUE > GREEN > RED | melanin synthesis |
| 797 | nras | 3 | 0.003 | BLUE = GREEN > RED | melanin synthesis |
| 1718 | camk2d | 4 | 0.022 | BLUE = GREEN > RED | melanin synthesis |
| 1939 | ep300 | 4 | 0.027 | RED > GREEN > BLUE | melanin synthesis |
| 2036 | plcb4 | 9 | 0.031 | BLUE > RED = GREEN | melanin synthesis |
| 2100 | wnt10b | 6 | 0.032 | RED > GREEN > BLUE | melanin synthesis |
| 2571 | oca2 | 3 | 0.048 | BLUE > RED = GREEN | melanin synthesis |
| 2620 | adcy3 | 2 | 0.050 | BLUE > GREEN > RED | melanin synthesis |
| 119 | xdh | 9 | 0.000 | RED = GREEN > BLUE | pteridine synthesis |
| 853 | spr | 2 | 0.004 | RED > GREEN > BLUE | pteridine synthesis |
| 975 | pts | 2 | 0.005 | GREEN > RED = BLUE | pteridine synthesis |
| 1282 | sox9 | 4 | 0.010 | GREEN > RED = BLUE | chromatophore differentiation |
| 167 | atp12a | 10 | 0.000 | BLUE > RED = GREEN | chromatophore differentiation |
| 280 | hps3 | 14 | 0.000 | BLUE > GREEN > RED | chromatophore differentiation |
| 1509 | hps4 | 5 | 0.016 | BLUE > RED = GREEN | chromatophore differentiation |
| 2260 | hps1 | 8 | 0.037 | BLUE > GREEN > RED | chromatophore differentiation |
| 2176 | myo5a | 2 | 0.034 | RED > GREEN > BLUE | chromatophore differentiation |
| 1180 | slc7a11 | 2 | 0.009 | GREEN > RED = BLUE | chromatophore differentiation |
| 316 | med1 | 7 | 0.000 | RED > GREEN > BLUE | chromatophore differentiation |
| 32 | egfr | 7 | 0.000 | BLUE = GREEN > RED | chromatophore differentiation |
| 55 | sult2b1 | 5 | 0.000 | BLUE > RED = GREEN | chromatophore differentiation |
| 128 | nf1 | 19 | 0.000 | RED = GREEN > BLUE | chromatophore differentiation |
| 327 | gpr161 | 5 | 0.000 | RED = GREEN > BLUE | chromatophore differentiation |
| 337 | fos | 4 | 0.000 | RED = GREEN > BLUE | chromatophore differentiation |
| 453 | gnpat | 10 | 0.001 | BLUE > RED = GREEN | chromatophore differentiation |
| 457 | mpzl3 | 1 | 0.001 | RED > BLUE > GREEN | chromatophore differentiation |
| 487 | srm | 5 | 0.001 | RED > BLUE > GREEN | chromatophore differentiation |
| 491 | atp6v1h | 3 | 0.001 | RED > BLUE > GREEN | chromatophore differentiation |
| 572 | mfsd12 | 5 | 0.001 | BLUE > RED = GREEN | chromatophore differentiation |
| 611 | cog4 | 14 | 0.001 | BLUE > RED = GREEN | chromatophore differentiation |
| 641 | dst | 11 | 0.002 | BLUE > GREEN > RED | chromatophore differentiation |
| 666 | oat | 4 | 0.002 | BLUE > RED = GREEN | chromatophore differentiation |
| 722 | slc24a4 | 5 | 0.002 | BLUE = GREEN > RED | chromatophore differentiation |
| 813 | mbtps1 | 6 | 0.003 | BLUE > GREEN > RED | chromatophore differentiation |
| 1022 | mlana | 5 | 0.006 | BLUE > RED = GREEN | chromatophore differentiation |
| 1053 | herc2 | 13 | 0.006 | RED > GREEN > BLUE | chromatophore differentiation |
| 1130 | adrb1 | 4 | 0.008 | RED > GREEN > BLUE | chromatophore differentiation |
| 1270 | casp3 | 3 | 0.010 | BLUE = RED > GREEN | chromatophore differentiation |
| 1271 | dock7 | 2 | 0.010 | BLUE > GREEN > RED | chromatophore differentiation |
| 1388 | atrn | 4 | 0.013 | RED > BLUE > GREEN | chromatophore differentiation |
| 1457 | ece1 | 6 | 0.015 | BLUE > RED = GREEN | chromatophore differentiation |
| 2086 | mgrn1 | 3 | 0.032 | GREEN > RED = BLUE | chromatophore differentiation |
| 2118 | med12 | 6 | 0.033 | RED > GREEN > BLUE | chromatophore differentiation |
| 2141 | atp6v1e1 | 3 | 0.033 | RED > BLUE > GREEN | chromatophore differentiation |
| 2438 | edn3 | 5 | 0.043 | GREEN > RED = BLUE | chromatophore differentiation |
| 2439 | gfpt1 | 4 | 0.043 | RED = GREEN > BLUE | chromatophore differentiation |
| 2468 | pnp | 3 | 0.044 | BLUE = RED > GREEN | chromatophore differentiation |
| 2500 | sf3b1 | 6 | 0.045 | BLUE > RED = GREEN | chromatophore differentiation |
| 2592 | rtf1 | 1 | 0.049 | BLUE = RED > GREEN | chromatophore differentiation |
| 2134 | impdh2 | 5 | 0.033 | BLUE > RED = GREEN | chromatophore differentiation |
| 800 | pax7 | 1 | 0.003 | GREEN > RED = BLUE | chromatophore differentiation |
For each gene, the number of transcripts compared, q-value, expression pattern and color-associated function are presented. The expression pattern represents the observed differences in mean transcript counts aggregated by gene and color morphs (see Fig. 2)