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. 2020 Apr 15;20:105. doi: 10.1186/s12876-020-01266-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Pathological findings of the CIC-rearranged sarcoma. a Cut surface of the pancreaticoduodenectomy specimen shows a pale tan-colored tumor in the duodenum accompanied by hemorrhage and necrosis. b A low-power photomicrograph shows focal lobulation within a fibrotic stroma (20x). c A high-power photomicrograph reveals proliferation of round neoplastic cells with mild pleomorphism and focally prominent nucleoli (hematoxylin and eosin stain, 40x). d Neoplastic cells are positive for WT1 (immunohistochemistry, 40x). e Neoplastic cells are positive for ETV4 (immunohistochemistry, 40x). f Fluorescence in situ hybridization using a CIC break-apart probe set demonstrates CIC rearrangement, showing 5′ green and 3′ red abnormal split signals (100x)