Table 1:

Concentration and size of EVs from 6 and 12 week WKY and SHR.

Animal	Age (weeks)	Individual Animal	Particles/mL	Particle Size (nm)
				Median	Mode	Mean
WKY	6	1	9.81×1009 ± 9.81×1008	135.6±5.7	145.3±12.6	149.9±59.4
		2	1.31×1010 ± 1.46×1009	150.6±7.3	151.8±13.2	171.1±70.3
		3	8.05×1009 ± 1.82×1009	146.2±7.4	149.6±15.9	163.8±63.8
		4	3.59×1010 ± 4.11×1009	133.3±5.4	138.9±12.3	148.3±60.6
		5	3.40×1010 ± 3.88×1009	142.7±5.1	149.1±12.8	155.5±54.6
		Average	2.00×1010 ± 1.38×1010	141.7 ± 7.2	146.9 ± 5.1	157.7 ± 9.6
WKY	12	1	5.23×1009 ± 6.55×1008	145.7±10.6	148.6±16.3	159.4±56.4
		2	7.59×1009 ± 8.50×1008	145.5±9.4	153.6±15.9	157.6±54.4
		3	1.06×1010 ± 1.78×1009	136.2±10.0	144.6±15.1	151.3±60.9
		4	4.89×1010 ± 7.47×1009	133.9±5.3	141.7±9.9	147.0±59.4
		5	1.48×1010 ± 1.70×1009	152.3±8.7	157.0±20.7	157.5±57.3
		6	1.04×1010 ± 3.75×1009	138.6±9.5	145.0±17.5	153.7±56.3
		7	6.49×1009 ± 6.69×1008	141.8±12.4	147.9±20.5	157.5±57.3
		Average	1.49×1010 ± 1.53×1010	142.0 ± 6.4	145.6 ± 4.2	154.9 ± 4.4
SHR	6	1	1.07×1010 ± 1.08×1009	143.7±6.7	152.4±11.4	155.1±57.9
		2	1.01×1010 ± 1.82×1009	134.3±33.9	143.3±37.3	156.3±59.5
		3	1.67×1010 ± 2.35×1009	136.7±6.0	147.1±14.1	148.2±55.7
		4	1.72×1010 ± 2.32×1009	137.3±3.6	143.0±14.0	150.4±55.5
		5	1.68×1010 ± 1.62×1009	138.6±7.9	142.4±15.4	151.4±50.2
		Average	1.43×1010 ± 3.57×1009	138.1 ± 3.5	148.3 ± 5.4	152.3 ± 3.4
SHR	12	1	1.24×1010 ± 6.33×1008	135.9±4.8	144.7±11.2	148.9±58.0
		2	1.49×1009 ± 2.25×1008	175.0±13.7	195.6±52.4	199.3±92.8
		3	6.79×1009 ± 4.70×1008	136.4±5.9	136.6±12.4	151.4±58.8
		4	1.15×1010 ± 1.12×1009	141.1±5.4	145.3±12.6	155.8±59.7
		5	3.25×1010 ± 2.78×1009	144.9±8.0	151.6±14.0	158.1±56.5
		6	5.34×1009 ± 4.07×1008	137.7±7.3	143.9±16.6	152.4±55.3
		7	1.91×1010 ± 3.23×1009	133.0±6.3	138.7±12.5	146.2±57.0
		Average	1.27×1010 ± 1.04×1010	143.4 ± 14.5	150.9 ± 20.3	158.9 ± 18.3

Data are mean ± s.d. One-way ANOVA.