Figure 20.15.

Cryptococcosis in the lungs of a slender-tailed cloud rat.

(A) The interstitium is moderately to markedly expanded and distorted by myriad fungal yeasts and associated histiocytic to granulomatous inflammation. Aggregates of lymphoplasmacytic inflammation can be seen but are typically infrequent. (B) Yeast vary in size, have narrow-based budding, and are surrounded by a thick mucopolysaccharide capsule that does not stain with hematoxylin and eosin and appears as a clear halo.

(Photos Courtesy of D. McAloose, Wildlife Conservation Society)