Table e3.
Summary of Parasites and Associated Diseases of Rodents
| Etiology | Location in Host | Associated Disease (if any) | Species Affected | References | |
|---|---|---|---|---|---|
| Metazoan | |||||
| Baylisascaris procylonis | Muliple systems | Granulomatous and eosinophilic inflammation from larval migrans | All | Bauer (2013) | |
| Capillaria hepatica (syn. Calodium hepaticum) | Liver | Multifocal granulomatous hepatitis with fibrosis | All | Rothenburger (2014a), Simpson (2013) | |
| Cysticercus fasciolaris | Liver | Parasitic cysts | Mice and rats | Morrisey (1996) | |
| Cysticercus mustelae | Liver | Parasitic cysts | Squirrels | Langham (1990) | |
| Cysticercus serialis (syn. Muticeps serialis) | Subcutaneous tissues, abdomen, liver, spleen, thorax | Parasitic cysts | Chinchilla | Morrisey (1996) | |
| Echinococcus cruzi (syn. oligarthrus) | Subcutaneous tissues, abdomen, liver, spleen, thorax | Parasitic cysts | Agouti | Rausch (1984), Zimmerman (2009) | |
| Echinococcus granulosus | Liver | Parasitic cysts | Ground squirrels (Spermophilus dauricus/alashanicus) | Yang (2009) | |
| Echinococcus multilocularis | Liver, other organs | Parasitic cysts | All | Janovsky (2002), Campbell-Palmer (2015), Miller (2016) | |
| Echinococcus vogeli | Liver, other organs | Parasitic cysts | Agoutis, spiny rats | Gardner (1988) | |
| Eucoleus sp. | Esophagus, stomach | Hyperplasia, hyperkeratosis, inflammation | Rats | Rothenburger (2014b) | |
| Gongylonema neoplasticum | Stomach | Hyperplasia, hyperkeratosis, inflammation | Rats | Hitchcock (1952) | |
| Hymenolepis sp. | Intestines | Diarrhea, enteritis | Chincilla, mice, rats, hamsters | Morrisey (1996) | |
| Obeliscoides cuniculi | Stomach | None | Woodchuck | Measures (1983) | |
| Synhimantus sp. | Stomach | Squamous papillomas | Muskrats | Cosgrove (1967) | |
| Syphacia sp. | Cecum | None | Mice, rats, hamsters | Morrisey (1996) | |
| Taenia crassiceps cysticercosis | Subcutaneous tissues, abdomen, liver, spleen, thorax | Parasitic cysts | Woodchuck, squirrel | Klein (2011) | |
| Trichosomoides crassicauda | Urinary bladder, renal pelvis | Mild inflammation, predisposes to calculi formation | Rats | Morrisey (1996) | |
| Protozoan | |||||
| Babesia sp. | Blood | None | Agouti, porcupine, spiny rat | de Thoisy (2000) | |
| Besnoitia sp. | Bone, inner ear, scleral conjunctiva, subcutaneous tissues, mesentery, large intestines, pancreas | Range from one to acute, fatal infections | Kangaroo rat, hamesters, mice, rats | Ernst (1968) | |
| Cryptosporidium sp. | Intestine | Diarrhea, enteritis | Chinchilla, guinea pig, hamster, rat, mice | Morrisey (1996) | |
| Eimeria sp. | Intestine | Diarrhea, enteritis | Guinea pig, rat, mice | Morrisey (1996) | |
| Encephalitozoon cuniculi | Brain, kidney, liver, heart, lung, spleen | Multisystemic inflammation & necrosis | All | Hinney (2016) | |
| Frenkelia | Brain | None, lymphoid hyperplasia, lymphocytic meningoencephalitis | All | Geisel (1979), Kennedy (1986) | |
| Giardia sp. | Intestine | Diarrhea, enteritis | Hamster, mice, rat | Morrisey (1996) | |
| Hepatozoon sp. | Mutliple organs, blood | None | Squirrel, porcupine | Simpson (2013), de Thoisy (2000) | |
| Klossiella sp. | Kidney | Interstitial nephritis and fibrosis | Guinea pigs, mice | Pearce (1961), Morrisey (1996) | |
| Leishmania lainsoni | Skin | None | Agouti | Silveira (1991) | |
| Pneumocystis carinii | Lungs | Interstitial pneumonia, perivascular lymphoid cuffs | All | Henderson (2012) | |
| Syphacia spp. | Cecum and colon | None to rectal prolapse, intussusception, enteritis | Mice and rats | Baker (1998) | |
| Spironucleus muris | Intestine | None to fatal enteritis | Mice and rats | Baker (1998) | |
| Toxoplasma gondii | Brain, liver, spleen, lung, skeletal muscle, heart | None to multisystemic inflammation & necrosis | all | Bangari (2007), Forzan (2004), Simpson (2013) | |
| Trypanosomatidae | Blood | None to thrombocytosis, ascites, immunodepression, lymphoid & erythroid hyperplasia | agouti, porcupine, spiny rat, Norway rats, mice | Albright (1991), de Thoisy (2000) | |
| Ectoparasite | |||||
| Chirodiscoides caviae | Skin | None | Guinea pigs | Morrisey (1996) | |
| Demodex | Skin | Alopecia, dermatitis, pruritis | Gerbil, hamster | Morrisey (1996) | |
| Gliricola porcelli | Skin | Alopecia, crusting dermatitis, pruritis | Guinea pigs | Morrisey (1996) | |
| Gyropus ovalis | Skin | Alopecia, crusting dermatitis, pruritis | Guinea pigs | Morrisey (1996) | |
| Myobia musculi | Skin | Alopecia, pruritis, self-mutilation | Mice | Baker (1998) | |
| Myocoptes musculinis | Skin | Alopecia, pruritis, self-mutilation | Mice | Morrisey (1996) | |
| Notoedres sp. | Skin | Alopecia, crusting dermatitis | Hamster, grey squirrel, rats | Anholt (2014), Cornish (2001), Morrisey (1996), Stephenson (2013) | |
| Ornithonyssus bacoti | Skin | Anemia | Rats | Morrisey (1996) | |
| Polyplax serrata | Skin | Anemia, pruritis, dermatitis | Mice | Morrisey (1996) | |
| Polyplax spinulosa | Skin | Anemia, pruritis | Rats | Morrisey (1996) | |
| Psoregates simplex | Skin | Follicular nodules | Mice | Morrisey (1996) | |
| Radfordia affinis | Skin | Alopecia, pruritis, self-mutilation | Mice | Baker (1998) | |
| Radfordia ensifera | Skin | Anemia, pruritis, dermatitis | Rats | Morrisey (1996) | |
| Trixacarus caviae | Skin | Alopecia, crusting dermatitis | Guinea pigs | Morrisey (1996) | |
Anholt, H., Himsworth, C., Rothenburger, J., Patrick, D.M. 2014. Ear mange mites (Notoedres muris) in black and Norway rats (Rattus rattus and Rattus norvegicus) from inner-city Vancouver, Canada. J. Wild. Dis. 50, 104–108.
Anholt, H., Himsworth, C., Rothenburger, J., Patrick, D.M. 2014. Ear mange mites (Notoedres muris) in black and Norway rats (Rattus rattus and Rattus norvegicus) from inner-city Vancouver, Canada. J. Wild. Dis. 50, 104–108.
Baker, D.G. 1998. Nathural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin. Microbiol Rev. 11, 231–266.
Bangari, D. S., Mouser, P., Miller, M. A., Stevenson, G. W., Vemulapalli, R., Thacker, H. L., 2007. Toxoplasmosis in a woodchuck (Marmota monax) and two American red squirrels (Tamiasciurus hudsonicus). J. Vet. Diagn. Invest. 19, 705–709.
Bauer, C., 2013. Baylisascariosis—Infections of animals and humans with ‘unusual’roundworms. Vet. Parasitol, 193, 404–412.
Campbell-Palmer, R., Del Pozo, J., Gottstein, B., Girling, S., Cracknell, J., Schwab, G., Rosell, F., Pizzi, R., 2015. Echinococcus multilocularis detection in live Eurasian beavers (Castor fiber) using a combination of laparoscopy and abdominal ultrasound under field conditions. PloS One 10, e0130842.
Cornish, T.E., Linders, M.J., Little, S.E., Vander Haegen, W.M. 2001. Notoedric mange in western gray squirrels from Washington. J. Wild. Dis. 37, 630–633.
Cosgrove, G. E., Lushbaugh, W. B., Humason, G., Anderson, M. G., 1968. Synhimantus (Nematoda) associated with gastric squamous tumors in muskrats. Bull. Wild. Dis. Assoc. 4, 54–57.
Ernst, J. V., Chobotar, B., Oaks, E. C., Hammond, D. M., 1968. Besnoitia jellisoni (Sporozoa: Toxoplasmea) in rodents from Utah and California. J. Parasitol. 54, 545–549.
de Thoisy, B., Michel, J. C., Vogel, I., Vié, J. C., 2000. A survey of hemoparasite infections in free-ranging mammals and reptiles in French Guiana. J. Parasitol. 86, 1035–1040.
Forzan, M. J., Frasca, S., 2004. Systemic toxoplasmosis in a five month old beaver, (Castor Canadensis). J. Zoo Wild. Med. 35, 113–115.
Gardner, S. L., Rausch, R. L., Camacho, O. C. J., 1988. Echinococcus vogeli Rausch and Bernstein, 1972, from the paca, Cuniculus paca l.(Rodentia: Dasyproctidae), in the Departamento de Santa Cruz, Bolivia. J. Parasitol. 74, 399–402.
Geisel, O., Kaiser, E., Vogel, O., Krampitz, H. E., Rommel, M., 1979. Pathomorphologic findings in short-tailed voles (Microtus agrestis) experimentally-infected with Frenkelia microti. J. Wildl. Dis. 15, 267–270.
Henderson, K. S., Dole, V., Parker, N. J., Momtsios, P., Banu, L., Brouillette, R., Simon, M. A., Albers, T. M., Pritchett-Corning, K. R., Clifford, C. B., Shek, W. R., 2012. Pneumocystis carinii causes a distinctive interstitial pneumonia in immunocompetent laboratory rats that had been attributed to “rat respiratory virus”. Vet. Path. 49, 440–452.
Hinney, B., Sak, B., Joachim, A., Kváč, M., 2016. More than a rabbit’s tale–Encephalitozoon spp. in wild mammals and birds. Int. J. Parasitol. Parasites Wildl., 5, 76–87.
Hitchcock, C. R., Bell, E. T., 1952. Studies on the nematode parasite, Gongylonema neoplasticum (Spiroptera neoplasticum) and avitaminosis A in the forestomach of rats: comparison with Fibiger’s results. J. Natl. Cancer Inst. 12, 1345–1388.
Janovsky, M., Bacciarini, L., Sager, H., Grone, A., Gottstein, B. 2002. Echinococcus multilocularis in a European beaver from Switzerland. J. Wild. Dis. 8, 618–620.
Kennedy, M. J., Frelier, P. F., 1986. Frenkelia sp. from the brain of a porcupine (Erethizon dorsatum) from Alberta, Canada. J. Wildl. Dis. 22, 112–114.
Klein, P. N., Driscoll, C. P., 2011. The role of wildlife rehabilitation as sentinels for One Health issues at the wildlife and public health interface: reports of Taenia crassiceps Cysticercosis in woodchucks (Marmota monax) and squirrels (Sciurus carolinensis) in Maryland and Virginia. WCV Call of the Wild Conference.
Langham, R. F., Rausch, R. L., Williams, J. F., 1990. Cysticerci of Taenia mustelae in the fox squirrel. J. Wild. Dis. 26, 295–296.
Measures, L. N., Anderson, R. C., 1983. Characteristics of natural infections of the stomach worm, Obeliscoides cuniculi (Graybill), in lagomorphs and woodchucks in Canada. J. Wildl. Dis. 19, 219–224.
Miller, A. L., Olsson, G. E., Walburg, M. R., Sollanberg, S., Skarin, M., Ley, C., Wahlstrom, H., Hoguln, J., 2016. First identification of Echinococcus multilocularis in rodent intermediate hosts in Sweden. Int. J. Parasitol. 5, 56–63.
Morrisey, J.K. 1996. Parasites of ferrets, rabbits, and rodents. J. Exotic Pet. Med. 5, 106–114.
Pearce, L. 1961. Klossiella infection of the guinea pig. J. Exp. Med. 23, 431–441.
Rausch, R. L., D’Alessandro, A., Ohbayashi, M., 1984. The taxonomic status of Echinococcus cruzi Brumpt and Joyeux, 1924 (Cestoda: Taeniidae) from an agouti (Rodentia: Dasyproctidae) in Brazil. J. Parasitol. 70, 295–302.
Rothenburger, J. L., Himsworth, C. G., Chang, V., Lejune, M., Leighton, F. A., 2014a. Capillaria hepatica in wild Norway Rats (Rattus norvegicus) from Vancouver, Canada. J. Wildl. Dis. 50, 628–633.
Rothenburger, J. L., Himsworth, C. G., Lejune, M., Treuting, P. M., Leighton, F. A., 2014b. Lesions associated with Eucoleus sp. in the non-glandular stomach of wild urban rats (Rattus norvegicus). Int. J. Parasitol. 3, 95–101.
Silveira, F. T., Lainson, R., Shaw, J. J., Braga, R. R., Ishikawa, E. E. A., Souza, A. A. A., 1991. Cutaneous leishmaniasis in the Amazon: isolation of Leishmania (V.) lainsoni rodent Agouti paca (Rodentia: Dasyproctidae) in the state of Para, Brazil. Rev. Inst. Med. Trop. S. Paolo. 33, 18–22.
Simpson, V. R., Hargreaves, J., Butler, H. M., Davison, N. J., Everest, D. J., 2013. Causes of mortality and pathological lesions observed post-mortem in red squirrels (Sciurus vulgaris) in Great Britain. BMC Vet. Res. 9, 229.
Stephenson, N., Swift, P., Villepique, J. T., Clifford, D. L., Nyaoke, A., De la Mora, A., Moore, J., Foley, J., 2013. Pathologic findings in Western gray squirrels (Sciurus griseus) from a notoedric mange epidemic in San Bernardino Moutnains, California. J. Parasitol. 2, 266–270.
Yang, Y. R., Liu, T., Bai, X., Boufana, B., Craig, P.S., Nakao, M., Ito, A., Zhang, J. Z., Giraudoux, P., McManus, D. P., 2009. Natural infection of the ground squirrel (Spermophilus spp.) with Echinococcus granulosus in China. PLoS Negl. Trop. Dis. 3, e518.
Zimmerman, D. M., Douglass, M., Reavill, D. R., Greiner, E. C., 2009. Echinococcus oligarthrus cystic hydatidosis in Brazilian agouti (Dasyprocta leporine). J. Zoo Wild. Med. 40, 551–558.