Table 3.3.
Mouse cell surface antigens: Non-CD antigens
| Non-CD antigens by alphanumeric order | ||||||
|---|---|---|---|---|---|---|
| Antigen | Other names | MW | Structure | Chromosome # | Expression | Function |
| 4-1BBL | Tnfsf9 TNFSF | 17 | Bact , DCact, peritoneal macact | DC activation, cytokine production | ||
| B7-H1 | PD-L1 | Broad | Cell costimulation, receptor for PD-1 | |||
| B7-H2 | GL50, ICOS-L, B7h, B7RP-1 | B, DC, mono | Cell costimulation, receptor for ICOS | |||
| B7-DC | PD-L2 | Mono, mac, DC subset | Cell costimulation, receptor for PD-1 | |||
| BP-1 | Ly-51, 6C3, Enpep | 120–160 kD | Type II TM | 3 | Early B progenitors, BM stromal cells, thymic epith | Zinc metalloproteinase, glutamyl aminopeptidase |
| DX5 | VLA-2, Integrin a2, Itga 2 | 165 kD | IntgF | 13 | NK, T subset | |
| Flk-1 | Kdr, Ly73, VEGFR2 | RTK family | 5 | Endoth | Receptor for VEGF | |
| Flt-4 | VEGFR3 | 170 kD | RTK family | 11 | Lymphatic endoth | Endoth growth factor receptor, binds VEGF-C |
| ICOS | Ly115 | 26 kD | IgSF | 1 | Thymic medulla, geminal center T cells, Tact | Inducible T cell Costimulator, T costimulation, B7-H2 receptor, cytokine production, B help |
| IgE high affinity receptor | B, mono | High affinity binding to IgE | ||||
| IgM | Surface expression by mature B cells | |||||
| Jagged-1 | Receptor for Notch-1 | |||||
| Ly-6A/E | Sca-1 | 18 kD | GPI-linked | Gran, mono, B, T subset, endoth | T activation | |
| Ly-6B | ||||||
| Ly-6C | 14–17 kD | GPI-linked | Endoth, T, NK, mono, mac | |||
| Ly-6D | ThB, Ly-61 | 15 kD | GPI-linked | B, T, thymic epith | ||
| Ly-6F | ||||||
| Ly-6G | Gr-1 | 21–25 kD | GPI-linked | Unknown | Myeloid cells | |
| Ly-49A | A1, Klra1 | 85 kD | Type II TM C-type lectin | 6 | T subset, NK subset | Regulation of cytotoxicity, binds MHC class I |
| Ly-49B | Klra2 | 6 | ||||
| Ly-49C | Klra3, 5E6 | 110 kD | Type II TM C-type lectin | 6 | T subset, NK subset | Regulation of cytotoxicity, binds MCH class I |
| Ly-49D | Klra4 | Type II TM C-type lectin | 6 | NK subset | NK activation | |
| Ly-49E | Klra5 | 6 | ||||
| Ly-49F | Klra6 | 6 | ||||
| Ly-49G | LGL1, Klra7 | 85 kD | Type II TM C-type lectin | 6 | T subset, NK subset | Regulation of cytotoxicity |
| Ly-49H | Klra8 | Type II TM C-type lectin | 6 | |||
| Ly-49I | Klra9 | Type II TM C-type lectin | 6 | |||
| Mac-3 | 93–110 kD | Mac (surface and intercellular) related to CD107b | ||||
| MAd-CAM-1 | 50 kD | IgSF, Type I TM | 10 | Endoth subset | Mucosal vascular addressin cell adhesion molecule, adhesion, cells homing, binds CD49d and CD62L | |
| Notch-1 | Lin-12, Tan1 | 2 | Developing embryo, variety of adult tissues | Cell-cell interaction, cell fate determination | ||
| OX-40 ligand | Tnfsf4, gp34 | 35 kD | TNFSF | 1 | Bact, cardiac myocytes | T-B interaction, T costimulation |
| PD-1 | Programmed death-1 | 55 kD | Thymocyte subset,Tact, Bact | T-B interaction, T costimulation, peripheral tolerance | ||
| Sca-1 | Sca-1 | 18 kD | GPI-linked | Gran, mono B, T subset, endoth | T activation | |
| Ter-119 | Ly-76 | Early proerythroblast to mature erythrocyte | W/glycophorin, but not a typical glycophorin | |||
| Tie2 | Tek | 140 kD | RTK family | 4 | Stem cells, endoth from early development | Angiogenesis, Angiopoietin-1 receptor |
| TLR1 | 5 | Activation of AP-1 not NF-kB | ||||
| TLR2 | 3 or 8 | Mono, mac, adipocytes, γδT | Response to bacterial lipoproteins | |||
| TLR3 | 3 or 8 | Binds double stranded RNA, activation of NK-kB | ||||
| TLR4 | Ly87, Rasl2-8 | 4 | Peritoneal mac | Bacterial lipoproteins response, NF-kB and AP-1 activation | ||
| TLR5 | 1 | mRNA: liver, lung, lower level in MOLF/Ei mice | Role in Gram-negative bacterial infection | |||
| TLR6 | 5 | mRNA: spleen, thymus, ovary, lung | Activation of NF-kB and JunK | |||
| TLR7 | X | |||||
| TLR8 | X | |||||
| TLR9 | 6 | CpG DNA receptor, TLR9KO resist lethal effect of CpG | ||||
| TRAIL | Ly-81, APO-2L, Tnfsf10 TNFSF | Unknown | NKact, liver NK | Apoptosis | ||
| TCR | αβ | T subset | Antigen recognition | |||
| TCR | γδ | T subset | Antigen recognition | |||
| TCR-Hy | Transgenic H-Y T cells | |||||
Abbreviations:
- Act
- Activatedy
- Ag
- Antigen
- BM
- Bone marrow
- CCRSF
- Complement component receptor superfamily
- CHO
- Carbohydrate moiety
- CRSF
- Cytokine receptor superfamily
- DC
- Dendritic cells
- ECM
- Extracellular matrix
- Endoth
- Endothelial cells
- Epith
- Epithelial cells
- FDC
- Follicular dendritic cells
- GPI
- Glycophosphatidylinositol
- Gran
- Granulocytes
- (H)
- Human CD, not defined in mouse
- IgSF
- Immunoglobulin superfamily
- IntgF
- Integrin family
- KO
- Knock-out mouse
- LRRF
- Leucine-rich repeat family
- Mac
- Macrophages
- MHC
- Major histocompatibility complex
- Mono
- Monocytes
- NK
- Natural killer
- RTK
- Receptor tyrosine kinase
- SRCRSF
- Scavenger receptor cysteine-rich superfamily
- TM
- Transmembrane
- TM12SF
- 12-transmembrane spanning protein superfamily
- TM4SF
- 4-transmembrane spanning protein superfamily
- TM7SF
- 7-transmembrane spanning protein superfamily
- TNFRSF
- TNF receptor superfamily
- TNFSF
- TNF superfamily
- TLRSF
- Toll-like receptor superfamily
- W/
- Associates with