Figure 14-16.

Neuronal Necrosis (Acute), So-Called Ischemic Cell Change, Cerebrum, Dog.

A, Neuronal ischemia. Neuronal cell bodies of cerebral cortical laminae are red, angular, and shrunken (arrows), and their nuclei are contracted and dense. This lesion can be caused by neuronal ischemia. H&E stain. B, Neuronophagia. This necrotic neuron cell body (center of figure) is surrounded and infiltrated by macrophages that will phagocytose the cell debris. H&E stain.

(A courtesy Dr. J.F. Zachary, College of Veterinary Medicine, University of Illinois. B courtesy Dr. M.D. McGavin, College of Veterinary Medicine, University of Tennessee.)