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. 2017 Feb 17:805–907.e1. doi: 10.1016/B978-0-323-35775-3.00014-X

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Copyright © 2017 Elsevier Inc. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Figure 14-54 — Prion Protein.

In prion diseases (spongiform encephalopathies), PrP (PrP^C), a normal neuronal protein, is converted to an abnormal β-pleated sheet isoform (PrP^Sc) through the interaction of PrP^Sc with PrP^C. ANS, Autonomic nervous system; CNS, central nervous system; GALT, gut-associated lymphoid tissue; PNS, peripheral nervous system.

(Courtesy Dr. A.D. Miller, College of Veterinary Medicine, Cornell University; and Dr. J.F. Zachary, College of Veterinary Medicine, University of Illinois.)