Figure 14-65.

Globoid Cell Leukodystrophy, Dog.

A, Spinal cord. This section of spinal cord has been stained with Luxol fast blue, a histochemical reaction that stains myelin blue. Note the loss of myelin from the periphery of the cord, where axons are heavily myelinated (arrows), the first area to be affected. Luxol fast blue stain with a nuclear fast red counterstain. B, Early stage of the disease. The white matter contains globoid cells (macrophages) that are characterized by abundant eosinophilic cytoplasm and an eccentric nucleus (arrows). The number and size of macrophages increase over the time course of the disease due to progressive loss of myelin. H&E stain.

(A courtesy Dr. M.D. McGavin, College of Veterinary Medicine, University of Tennessee; B courtesy Dr. A.D. Miller, College of Veterinary Medicine, Cornell University.)