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Globoid Cell Leukodystrophy, Cerebrum. Dog.
Late stage of the disease. Globoid cells deficient in β-galactocerebrosidase (arrows), usually located in the perivascular space, increase in size and number because they are unable to degrade galactocerebroside to a less complex substrate. H&E stain.
(Courtesy Dr. M.D. McGavin, College of Veterinary Medicine, University of Tennessee.)
