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. 2017 Feb 17:805–907.e1. doi: 10.1016/B978-0-323-35775-3.00014-X

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Copyright © 2017 Elsevier Inc. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Figure 14-97 — Canine Distemper, Dog.

A, Acute polioencephalomyelitis. Hippocampus. Note the necrotic neurons (arrows) and edema of the dentate gyrus. Low numbers of mononuclear inflammatory cells are present. H&E stain. B, Inclusion bodies, brain, midbrain periventricular white matter, dog. Distinct acidophilic (red) intranuclear inclusion bodies (arrows) are present in astrocytes and some gemistocytes. Similar inclusions can be observed in the cytoplasm of epithelial cells throughout the body (bladder epithelium, respiratory epithelium, gastric epithelium). H&E stain.

(A courtesy Dr. W. Haschek-Hock, College of Veterinary Medicine, University of Illinois. B courtesy Dr. M.D. McGavin, College of Veterinary Medicine, University of Tennessee.)