Figure 14-110.

Neuro-Pododermatitis (Acral Mutilation Syndrome), Dog.

This disorder, a primary sensory peripheral neuronopathy with self-mutilation and insensitivity to pain, is caused by the absence of (or small) dorsal root ganglia, reduction in size of dorsal nerve rootlets, and degeneration and loss of myelinated and nonmyelinated sensory axons. This dog wore off its footpads when placed on a concrete run. Satellite cell proliferation is commonly present in other large autonomic ganglia (i.e., celiac ganglion).

(Courtesy College of Veterinary Medicine, University of Illinois.)