Table 14-5.
Transmissible Spongiform Encephalopathies (i.e., Prion Diseases)
| Disease | Natural Host(s) | Prion | Pathogenic PrP Isoform |
|---|---|---|---|
| ANIMALS | |||
| Ovine spongiform encephalopathy (scrapie) | Sheep, goats | Scrapie prion | OvPrPSc |
| Bovine spongiform encephalopathy (BSE) | Cows | BSE prion | BoPrPSc |
| Feline spongiform encephalopathy (FSE) | Cats | FSE prion | FePrPSc |
| Chronic wasting disease (CWD) Transmissible mink encephalopathy (TME) |
Mule deer, elk, black-tailed deer, white-tailed deer, mink | CWD prion TME prion |
MdePrPSc MkPrPSc |
| Exotic ungulate encephalopathy (EUE) | Nyala, greater kudu, oryx | EUE prion | UngPrPSc |
| HUMAN BEINGS | |||
| Kuru | Human beings | Kuru prion | HuPrPSc |
| Creutzfeldt-Jakob disease (CJD) | Human beings | CJD prion | HuPrPSc |
| Variant Creutzfeldt-Jakob disease (VCJD) | Human beings | VCJD prion | HuPrPSc |
| Gerstmann-Sträussler-Scheinker syndrome (GSS) | Human beings | GSS prion | HuPrPSc |
| Fatal familial insomnia (FFI) | Human beings | FFI prion | HuPrPSc |