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. 2020 Jan 1;107(4):1004–1013. doi: 10.1002/cpt.1695

Figure 3.

Figure 3

Effect of rifampicin on the plasma concentration time profiles of various endogenous substrates. Plasma concentrations of the endogenous substrates were determined at designated times in healthy volunteers treated with or without an oral dose of rifampicin (150, 300, and 600 mg). Each symbol and vertical bar represent the mean and SEM (n = 8), respectively. C4, 7‐hydroxy‐4cholesten‐3‐one; CA, cholate; CDCA, chenodeoxycholate; CDCA‐24G, chenodeoxycholate‐24‐glucuronide; CP‐I, coproporphyrin I; D‐Bil, direct bilirubins; DCA, deoxycholate; GCA, glycocholate; GCDCA, glycochenodexoxycholate; GCDCA‐G, glycochenodeoxycholate‐3‐glucuronide; GCDCA‐S, glycochenodeoxycholate‐3‐sulfate; GDCA, glycodeoxycholate; GDCA‐G, glycodeoxycholate‐3‐glucuronide; GDCA‐S, glycodeoxycholate‐3‐sulfate; GLCA, glycolithocholate; GLCA‐S, glycolithocholate‐3‐sulfate; HDA, hexadecanedioic acid; LCA‐S, lithocholate‐3‐sulfate; ODA, octadecanedioate; T‐Bil, total bilirubins; TCA, taurocholate; TCDCA, taurochenodeoxycholate; TDA, tetradecanedioate; TDCA, taurodeoxycholate; TLCA‐S, taurolithocholate‐3‐sulfate; TUDCA, tauroursodeoxycholate.