Figure 6-33.

Neoplastic effusion. Mesothelioma. Same case A-C. A, Pleural. Dog.

The neoplastic cells are present as individual cells and in small clusters. The nucleoli are variably shaped and very prominent. (Romanowsky; HP oil.) B, These cells contain a variable amount of cytoplasm with one or more nuclei. The nuclei may be of odd number and variable size. (Romanowsky; HP oil.) C, The nuclear chromatin is coarsely granular and irregularly clumped with large prominent nucleoli. Many cells retain the fringed glycocalyx border. Also present are low numbers of small lymphocytes, neutrophils, and red blood cells. (Romanowsky; HP oil.)