TABLE 19.1.
Cluster Designation (CD) Markers Relevant to the Male Reproductive Tracta
| Marker | Gene Name, Common or Superseded Designation(s) | Function(s) |
|---|---|---|
| CD1 | Ly-38, R3 (CD1D) | Nonclassical MHC; presentation of lipid and glycolipid antigens |
| CD3 | T3, Leu 4 | Signaling component of the TCR complex |
| CD4 | T4, Leu 3 | Co-receptor for recognition of MHC class II; component of the TCR complex |
| CD8 | Ly-2, Ly-3, T8, Leu 2 | Co-receptor for recognition of MHC class I; component of the TCR complex |
| CD11a CD11b CD11c |
ITGAL, LFA-1, Ly-15, Ly-21 ITGAM, Mac-1, Ly-40 ITGAX, Leu M5 |
Integrin α chains; adhesion molecules, expressed on leukocytes |
| CD14 | LPS-R | Lipopolysaccharide-binding protein complex co-receptor; TLR4 co-receptor |
| CD16 | FCGR3, FcγRIII, Ly-17 | Receptor for Fc fragment of immunoglobulin G; expressed on subset of NK cells |
| CD18 | ITGB2, LCAMB | Integrin β2; adhesion molecule, pairs with CD11 |
| CD25 | IL2RA, Ly-43 | IL2 receptor α chain; marker for activated and Treg cells |
| CD28 | T44 | Receptor for CD80 and CD86; expressed on activated T cells, NK cells |
| CD30 | TNFRSF8 | TNF receptor superfamily, member 8; expressed on activated T cells, B cells |
| CD40 | TNFRSF5 | TNF receptor superfamily, member 5; co-stimulatory receptor; expressed on antigen-presenting cells |
| CD45 | PTPRC, LCA, Ly-5, T200 | Protein tyrosine phosphatase, receptor type, C; leukocyte common antigen; expressed on all leukocytes |
| CD46 | MCP | Membrane cofactor protein; complement regulatory protein |
| CD52 | CAMPATH-1 antigen | Complement regulatory protein; Treg co-stimulatory co-receptor |
| CD54 | ICAM1, Ly-47 | Intercellular cell adhesion molecule-1; expressed on activated endothelial cells |
| CD55 | DAF | Decay accelerating factor for complement; complement regulatory protein |
| CD56 | NCAM1 | Neural cell adhesion molecule-1; specific variant expressed on NK cells |
| CD59 | MAC-IP | Membrane attack complex inhibition factor; complement regulatory protein |
| CD68 | Macrosialin | Lysosomal membrane glycoprotein; expressed by dendritic cells, monocytes, some macrophages |
| CD80 | B7-1, B7/BB1, Ly-53 | Co-stimulatory co-receptor; ligand for CD28; expressed on antigen-presenting cells |
| CD86 | B7-2, Ly-58 | Co-stimulatory co-receptor; ligand for CD28; expressed on antigen-presenting cells |
| CD95 | FAS, APO-1 | Receptor for CD95 ligand; mediates apoptosis; expressed on activated lymphocytes |
| CD106 | VCAM1 | Vascular cell adhesion molecule-1; expressed on activated endothelial cells |
| CD126 | IL6R | Interleukin-6 receptor subunit; pairs with interleukin-6 signal transducer |
| CD130 | IL6ST, gp130 | Interleukin-6 signal transducer |
| CD152 | CTLA4 | Cytotoxic T-lymphocyte-associated antigen 4; inhibitory receptor for CD80 and CD86; expressed on T cells |
| CD154 | CD40LG | Ligand for CD40; co-stimulatory co-receptor; expressed on T cells |
| CD163 | M130 | Scavenger receptor for hemoglobin-haptoglobin complex; expressed on macrophage subset (M2) |
| CD206 | MRC1 | Macrophage mannose receptor 1; expressed on macrophage subset (M2) |
a
Refer to text for full details. Note that some designations represent multiple protein members.