TABLE 23-3.

Dosage Recommendations, Contraindications, Potential Drug Interactions, and Clinical Indications for Dosage Adjustments for the Common Antiemetic and Prokinetic Drugs Used to Treat Vomiting in Cats

Drug	Dosage (Cats)	C: Contraindications DI: Drug Interactions DA: Dosage Adjustments
Metoclopramide	0.2-0.4 mg/kg SC, PO q8h 1-2 mg/kg/day CRI	C: GI obstruction DI: Phenothiazines: extrapyramidal signs DA: Azotemia
Dolasetron Ondansetron	0.5-1.0 mg/kg IV, SC, PO q12-24h 0.22-0.5 mg/kg IV, PO q8-12h	DI: Cisapride: prolonged QT interval and arrhythmias
Maropitant	1 mg/kg IV, SC, PO q24h (up to 5 days)
Phenothiazines prochlorperazine chlorpromazine	0.2-0.4 mg/kg SC q8h	C: Dehydration; hypotension; seizure hx DI: Metoclopramide: extrapyramidal signs
Cisapride	1.5 mg/kg PO q12h	C: GI obstruction DI: Dolasetron: prolonged QT interval and arrhythmias; azole antifungals: inhibition CYP3A isoenzyme
Mirtazapine	1.88 mg/cat PO q48h	DI: Concurrent administration with other MAO inhibitors (i.e., selegiline, amitraz, tramadol, amitriptyline, clomipramine) and/or SSRIs (i.e., fluoxetine) contraindicated DA: Kidney or liver dysfunction

CRI, Constant rate infusion; hx, history.