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. 2017 Feb 17:724–804.e2. doi: 10.1016/B978-0-323-35775-3.00013-8

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Copyright © 2017 Elsevier Inc. All rights reserved.

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Figure 13-18 — Mechanisms of Neutrophilic Leukocytosis.

1, Neutrophils and their precursors are distributed in five pools: a bone marrow precursor pool, which includes mitotically active and inactive immature cells; a bone marrow storage pool, consisting of mitotically inactive mature neutrophils; a peripheral blood marginating pool; a peripheral blood circulating pool; and a tissue pool. The relative size of each pool is represented by the size of its corresponding wedge. The peripheral blood neutrophil count measures only neutrophils within the circulating peripheral blood pool, which can be enlarged by (2) increased demargination, (3) diminished extravasation into tissue, (4) increased release of cells from the marrow storage pool, and (5) expansion of the marrow precursor pool.

(Courtesy Dr. K.M. Boes, College of Veterinary Medicine, Virginia Polytechnic Institute and State University; and Dr. J.F. Zachary, College of Veterinary Medicine, University of Illinois.)