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Neonatal Isoerythrolysis, Foal.
Note the enlarged spleen (S) (also liver [L]) and icterus. The newborn foal had colostrum-derived maternal antibodies, which reacted against its own erythrocytes. Macrophages in the splenic red pulp remove erythrocytes whose membranes have bound antibody.
(Courtesy College of Veterinary Medicine, University of Illinois.)
