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. 2017 Feb 17:724–804.e2. doi: 10.1016/B978-0-323-35775-3.00013-8

Table 13-2.

Causes of Regenerative and Nonregenerative Anemia

Regenerative Anemia Nonregenerative Anemia
  • Hemorrhage
    • Trauma
    • Hemostasis defect
    • Neoplasia
    • Gastrointestinal ulceration
    • Parasitism
    • Phlebotomy
  • Primary bone marrow disease
    • Immune-mediated
    • Infections (e.g., feline leukemia virus)
    • Myelophthisis (e.g., myelitis, leukemia, myelofibrosis)
    • Toxicity (e.g., chemotherapeutic agents, estrogen, bracken fern)
    • Congenital disorders
  • Hemolysis
    • Immune-mediated
    • Infections (e.g., hemoparasitism)
    • Toxicity (oxidants)
    • Mechanical fragmentation (e.g., disseminated intravascular coagulation)
    • Enzymatic (e.g., bacterial phospholipases)
    • Neoplasia (e.g., hemophagocytic histiocytic sarcoma)
    • Hypophosphatemia
    • Congenital disorders
  • Extramarrow disease
    • Inflammatory disease
    • Chronic renal failure
    • Liver disease or failure
    • Endocrinopathies (e.g., hypoadrenocorticism, hypothyroidism)
    • Nutritional deficiency (e.g., iron deficiency, vitamin B12 deficiency, malnutrition)