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. 2015 Apr 3:407–435.e18. doi: 10.1016/B978-1-4557-3383-5.00025-7

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eFigure 25-11 — Subdivisions of the Dl_co.

Experimental values of the diffusing capacity for carbon monoxide (Dl_CO) obtained at different alveolar Po₂ values (x-axis in B) can be analyzed mathematically to obtain the subdivisions of total Dl_CO: the diffusing capacity of the membrane (Dm) and pulmonary capillary blood volume (Vc). As the alveolar Po₂ was increased from 40 mm Hg to 600 mm Hg, the duplicate measurements of Dl_CO decreased from approximately 45 to 15 mL/min per mm Hg. Changing alveolar Po₂ changes the reaction coefficient (θ), reflecting the change in hemoglobin affinity for carbon monoxide. The reaction coefficient is plotted against 1/Dl_CO in A. There is a linear relationship between 1/Dl_CO and 1/θ such that 1/Dl_CO = 1/θVc + 1/Dm. Under these conditions, Dm is derived from the value of the y-intercept and Vc from the slope of the line.