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. 2017 Nov 17:709–842. doi: 10.1016/B978-0-323-44329-6.00012-7

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Fig. 12.10 — Ultrastructural appearance of repairing ischemic-injured mucosa. (A) Restituting epithelium 2 hours after a 1-hour ischemic episode in the presence of the nonselective cyclooxygenase inhibitor indomethacin. Note dilation of the interepithelial space and the apical tight junction (arrows), which correlates with a “leaky” intestinal barrier. (B) Similar restituting epithelium that has been additionally treated with PGE₂ and PGI₂. Note the close apposition of the tight junction (arrows) and the interepithelial space correlated with normalization of intestinal barrier function. 1-cm bar = 6 μm.